Protein cereblon
1_MAGEG 6_ DQQDA 11_ AHNMG 16_ NHLPL 21_ LPAES 26_ EEEDE 31_ MEVED 36_ QDSKE 41_ AKKPN 46_ IINFD 51_ TSLPT 56_ SHTYL 61_ GADME 66_ EFHGR 71_ TLHDD 76_ DSCQV 81_ IPVLP 86_ QVMMI 91_ LIPGQ 96_ TLPLQ 101_ LFHPQ 106_ EVSMV 111_ RNLIQ 116_ KDRTF 121_ AVLAY 126_ SNVQE 131_ REAQF 136_ GTTAE 141_ IYAYR 146_ EEQDF 151_ GIEIV 156_ KVKAI 161_ GRQRF 166_ KVLEL 171_ RTQSD 176_ GIQQA 181_ KVQIL 186_ PECVL 191_ PSTMS 196_ AVQLE 201_ SLNKC 206_ QIFPS 211_ KPVSR 216_ EDQCS 221_ YKWWQ 226_ KYQKR 231_ KFHCA 236_ NLTSW 241_ PRWLY 246_ SLYDA 251_ ETLMD 256_ RIKKQ 261_ LREWD 266_ ENLKD 271_ DSLPS 276_ NPIDF 281_ SYRVA 286_ ACLPI 291_ DDVLR 296_ IQLLK 301_ IGSAI 306_ QRLRC 311_ ELDIM 316_ NKCTS 321_ LCCKQ 326_ CQETE 331_ ITTKN 336_ EIFSL 341_ SLCGP 346_ MAAYV 351_ NPHGY 356_ VHETL 361_ TVYKA 366_ CNLNL 371_ IGRPS 376_ TEHSW 381_ FPGYA 386_ WTVAQ 391_ CKICA 396_ SHIGW 401_ KFTAT 406_ KKDMS 411_ PQKFW 416_ GLTRS 421_ ALLPT 426_ IPDTE 431_ DEISP 436_DKVIL
1: Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2, ILF2 or GLUL (PubMed:26990986, PubMed:33009960). Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (PubMed:20223979, PubMed:24328678, PubMed:25043012, PubMed:25108355). Maintains presynaptic glutamate release and consequently cognitive functions, such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons (PubMed:18414909, PubMed:29530986). Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1 (PubMed:18414909). May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism (By similarity). Plays a negative role in TLR4 signaling by interacting with TRAF6 and ECSIT, leading to inhibition of ECSIT ubiquitination, an important step of the signaling (PubMed:31620128)