Integrator complex subunit 14 (von Willebrand factor A domain-containing protein 9)
1_MPTVV 6_ VMDVS 11_ LSMTR 16_ PVSIE 21_ GSEEY 26_ QRKHL 31_ AAHGL 36_ TMLFE 41_ HMATN 46_ YKLEF 51_ TALVV 56_ FSSLW 61_ ELMVP 66_ FTRDY 71_ NTLQE 76_ ALSNM 81_ DDYDK 86_ TCLES 91_ ALVGV 96_ CNIVQ 101_ QEWGG 106_ AIPCQ 111_ VVLVT 116_ DGCLG 121_ IGRGS 126_ LRHSL 131_ ATQNQ 136_ RSESN 141_ RFPLP 146_ FPFPS 151_ KLYIM 156_ CMANL 161_ EELQS 166_ TDSLE 171_ CLERL 176_ IDLNN 181_ GEGQI 186_ FTIDG 191_ PLCLK 196_ NVQSM 201_ FGKLI 206_ DLAYT 211_ PFHAV 216_ LKCGH 221_ LTADV 226_ QVFPR 231_ PEPFV 236_ VDEEI 241_ DPIPK 246_ VINTD 251_ LEIVG 256_ FIDIA 261_ DISSP 266_ PVLSR 271_ HLVLP 276_ IALNK 281_ EGDEV 286_ GTGIT 291_ DDNED 296_ ENSAN 301_ QIAGK 306_ IPNFC 311_ VLLHG 316_ SLKVE 321_ GMVAI 326_ VQLGP 331_ EWHGM 336_ LYSQA 341_ DSKKK 346_ SNLMM 351_ SLFEP 356_ GPEPL 361_ PWLGK 366_ MAQLG 371_ PISDA 376_ KENPY 381_ GEDDN 386_ KSPFP 391_ LQPKN 396_ KRSYA 401_ QNVTV 406_ WIKPS 411_ GLQTD 416_ VQKIL 421_ RNARK 426_ LPEKT 431_ QTFYK 436_ ELNRL 441_ RKAAL 446_ AFGFL 451_ DLLKG 456_ VADML 461_ ERECT 466_ LLPET 471_ AHPDA 476_ AFQLT 481_ HAAQQ 486_ LKLAS 491_ TGTSE 496_ YAAYD 501_ QNITP 506_ LHTDF 511_SGSST
1: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683, PubMed:38823386). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:32647223). Within the integrator complex, INTS14 is part of the integrator tail module that acts as a platform for the recruitment of transcription factors at promoters (PubMed:38823386, PubMed:38906142)