Mitochondrial tRNA methylthiotransferase CDK5RAP1 (EC 2.8.4.3) (CDK5 activator-binding protein C42) (CDK5 regulatory subunit-associated protein 1) (mt-tRNA-2-methylthio-N6-dimethylallyladenosine synthase) (mt-tRNA-N6-(dimethylallyl)adenosine(37) methylthiotransferase)
1_MHPLQ 6_ CVLQV 11_ QRSLG 16_ WGPLA 21_ SVSWL 26_ SLRMC 31_ RAHSS 36_ LSSTM 41_ CPSPE 46_ RQEDG 51_ ARKDF 56_ SSRLA 61_ AGPTF 66_ QHFLK 71_ SASAP 76_ QEKLS 81_ SEVED 86_ PPPYL 91_ MMDEL 96_ LGRQR 101_ KVYLE 106_ TYGCQ 111_ MNVND 116_ TEIAW 121_ SILQK 126_ SGYLR 131_ TSNLQ 136_ EADVI 141_ LLVTC 146_ SIREK 151_ AEQTI 156_ WNRLH 161_ QLKAL 166_ KTRRP 171_ RSRVP 176_ LRIGI 181_ LGCMA 186_ ERLKE 191_ EILNR 196_ EKMVD 201_ ILAGP 206_ DAYRD 211_ LPRLL 216_ AVAES 221_ GQQAA 226_ NVLLS 231_ LDETY 236_ ADVMP 241_ VQTSA 246_ SATSA 251_ FVSIM 256_ RGCDN 261_ MCSYC 266_ IVPFT 271_ RGRER 276_ SRPIA 281_ SILEE 286_ VKKLS 291_ EQVFL 296_ PPRPP 301_ KVLGL 306_ QGLKE 311_ VTLLG 316_ QNVNS 321_ FRDNS 326_ EVQFN 331_ SAVPT 336_ NLSRG 341_ FTTNY 346_ KTKQG 351_ GLRFA 356_ HLLDQ 361_ VSRVD 366_ PEMRI 371_ RFTSP 376_ HPKDF 381_ PDEVL 386_ QLIHE 391_ RDNIC 396_ KQIHL 401_ PAQSG 406_ SSRVL 411_ EAMRR 416_ GYSRE 421_ AYVEL 426_ VHHIR 431_ ESIPG 436_ VSLSS 441_ DFIAG 446_ FCGET 451_ EEDHV 456_ QTVSL 461_ LREVQ 466_ YNMGF 471_ LFAYS 476_ MRQKT 481_ RAYHR 486_ LKDDV 491_ PEEVK 496_ LRRLE 501_ ELITI 506_ FREEA 511_ TKANQ 516_ TSVGC 521_ TQLVL 526_ VEGLS 531_ KRSAT 536_ DLCGR 541_ NDGNL 546_ KVIFP 551_ DAEME 556_ DVNNP 561_ GLRVR 566_ AQPGD 571_ YVLVK 576_ ITSAS 581_ SQTLR 586_ GHVLC 591_ RTTLR 596_DSSAY
1: Methylthiotransferase that catalyzes the conversion of N6-(dimethylallyl)adenosine (i(6)A) to 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 (adjacent to the 3'-end of the anticodon) of four mitochondrial DNA-encoded tRNAs (Ser(UCN), Phe, Tyr and Trp) (PubMed:22422838, PubMed:25738458, PubMed:28981754). Essential for efficient and highly accurate protein translation by the ribosome (PubMed:22422838, PubMed:25738458, PubMed:28981754). Specifically inhibits CDK5 activation by CDK5R1 (PubMed:11882646). Essential for efficient mitochondrial protein synthesis and respiratory chain; shows pathological consequences in mitochondrial disease (PubMed:25738458)