RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15)
1_MRTAG 6_ RDPVP 11_ RRSPR 16_ WRRAV 21_ PLCET 26_ SAGRR 31_ VTQLR 36_ GDDLR 41_ RPATM 46_ KGKER 51_ SPVKA 56_ KRSRG 61_ GEDST 66_ SRGER 71_ SKKLG 76_ GSGGS 81_ NGSSS 86_ GKTDS 91_ GGGSR 96_ RSLHL 101_ DKSSS 106_ RGGSR 111_ EYDTG 116_ GGSSS 121_ SRLHS 126_ YSSPS 131_ TKNSS 136_ GGGES 141_ RSSSR 146_ GGGGE 151_ SRSSG 156_ AASSA 161_ PGGGD 166_ GAEYK 171_ TLKIS 176_ ELGSQ 181_ LSDEA 186_ VEDGL 191_ FHEFK 196_ RFGDV 201_ SVKIS 206_ HLSGS 211_ GSGDE 216_ RVAFV 221_ NFRRP 226_ EDARA 231_ AKHAR 236_ GRLVL 241_ YDRPL 246_ KIEAV 251_ YVSRR 256_ RSRSP 261_ LDKDT 266_ YPPSA 271_ SVVGA 276_ SVGGH 281_ RHPPG 286_ GGGGQ 291_ RSLSP 296_ GGAAL 301_ GYRDY 306_ RLQQL 311_ ALGRL 316_ PPPPP 321_ PPLPR 326_ DLERE 331_ RDYPF 336_ YERVR 341_ PAYSL 346_ EPRVG 351_ AGAGA 356_ APFRE 361_ VDEIS 366_ PEDDQ 371_ RANRT 376_ LFLGN 381_ LDITV 386_ TESDL 391_ RRAFD 396_ RFGVI 401_ TEVDI 406_ KRPSR 411_ GQTST 416_ YGFLK 421_ FENLD 426_ MSHRA 431_ KLAMS 436_ GKIII 441_ RNPIK 446_ IGYGK 451_ ATPTT 456_ RLWVG 461_ GLGPW 466_ VPLAA 471_ LAREF 476_ DRFGT 481_ IRTID 486_ YRKGD 491_ SWAYI 496_ QYESL 501_ DAAHA 506_ AWTHM 511_ RGFPL 516_ GGPDR 521_ RLRVD 526_ FADTE 531_ HRYQQ 536_ QYLQP 541_ LPLTH 546_ YELVT 551_ DAFGH 556_ RAPDP 561_ LRGAR 566_ DRTPP 571_ LLYRD 576_ RDRDL 581_ YPDSD 586_ WVPPP 591_ PPVRE 596_ RSTRT 601_ AATSV 606_ PAYEP 611_ LDSLD 616_ RRRDG 621_ WSLDR 626_ DRGDR 631_ DLPSS 636_ RDQPR 641_ KRRLP 646_ EESGG 651_ RHLDR 656_ SPESD 661_ RPRKR 666_ HCAPS 671_ PDRSP 676_ ELSSS 681_ RDRYN 686_ SDNDR 691_ SSRLL 696_ LERPS 701_ PIRDR 706_ RGSLE 711_ KSQGD 716_ KRDRK 721_ NSASA 726_ ERDRK 731_ HRTTA 736_ PTEGK 741_ SPLKK 746_ EDRSD 751_ GSAPS 756_ TSTAS 761_ SKLKS 766_ PSQKQ 771_ DGGTA 776_ PVASA 781_ SPKLC 786_ LAWQG 791_ MLLLK 796_ NSNFP 801_ SNMHL 806_ LQGDL 811_ QVASS 816_ LLVEG 821_ STGGK 826_ VAQLK 831_ ITQRL 836_ RLDQP 841_ KLDEV 846_ TRRIK 851_ VAGPN 856_ GYAIL 861_ LAVPG 866_ SSDSR 871_ SSSSS 876_ AASDT 881_ ATSTQ 886_ RPLRN 891_ LVSYL 896_ KQKQA 901_ AGVIS 906_ LPVGG 911_ NKDKE 916_ NTGVL 921_ HAFPP 926_ CEFSQ 931_ QFLDS 936_ PAKAL 941_ AKSEE 946_ DYLVM 951_ IIVRG 956_ FGFQI 961_ GVRYE 966_ NKKRE 971_NLALT
1: RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311)