Protein phosphatase 1 regulatory inhibitor subunit 16B (Ankyrin repeat domain-containing protein 4) (CAAX box protein TIMAP) (TGF-beta-inhibited membrane-associated protein) (hTIMAP)
1_MASHV 6_ DLLTE 11_ LQLLE 16_ KVPTL 21_ ERLRA 26_ AQKRR 31_ AQQLK 36_ KWAQY 41_ EQDLQ 46_ HRKRK 51_ HERKR 56_ STGGR 61_ RKKVS 66_ FEASV 71_ ALLEA 76_ SLRND 81_ AEEVR 86_ YFLKN 91_ KVSPD 96_ LCNED 101_ GLTAL 106_ HQCCI 111_ DNFEE 116_ IVKLL 121_ LSHGA 126_ NVNAK 131_ DNELW 136_ TPLHA 141_ AATCG 146_ HINLV 151_ KILVQ 156_ YGADL 161_ LAVNS 166_ DGNMP 171_ YDLCE 176_ DEPTL 181_ DVIET 186_ CMAYQ 191_ GITQE 196_ KINEM 201_ RVAPE 206_ QQMIA 211_ DIHCM 216_ IAAGQ 221_ DLDWI 226_ DAQGA 231_ TLLHI 236_ AGANG 241_ YLRAA 246_ ELLLD 251_ HGVRV 256_ DVKDW 261_ DGWEP 266_ LHAAA 271_ FWGQM 276_ QMAEL 281_ LVSHG 286_ ASLSA 291_ RTSMD 296_ EMPID 301_ LCEEE 306_ EFKVL 311_ LLELK 316_ HKHDV 321_ IMKSQ 326_ LRHKS 331_ SLSRR 336_ TSSAG 341_ SRGKV 346_ VRRAS 351_ LSDRT 356_ NLYRK 361_ EYEGE 366_ AILWQ 371_ RSAAE 376_ DQRTS 381_ TYNGD 386_ IRETR 391_ TDQEN 396_ KDPNP 401_ RLEKP 406_ VLLSE 411_ FPTKI 416_ PRGEL 421_ DMPVE 426_ NGLRA 431_ PVSAY 436_ QYALA 441_ NGDVW 446_ KVHEV 451_ PDYSM 456_ AYGNP 461_ GVADA 466_ TPPWS 471_ SYKEQ 476_ SPQTL 481_ LELKR 486_ QRAAA 491_ KLLSH 496_ PFLST 501_ HLGSS 506_ MARTG 511_ ESSSE 516_ GKAPL 521_ IGGRT 526_ SPYSS 531_ NGTSV 536_ YYTVT 541_ SGDPP 546_ LLKFK 551_ APIEE 556_ MEEKV 561_HGCCR
1: Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function (PubMed:18586956). Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation (PubMed:25007873). Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (By similarity). Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage (By similarity). Involved in the regulation of endothelial cell filopodia extension (By similarity). May be a downstream target for TGF-beta1 signaling cascade in endothelial cells (PubMed:16263087, PubMed:18586956). Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation (PubMed:18586956). Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 (PubMed:16263087). Involved in the dephosphorylation of EEF1A1 (PubMed:26497934)