RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (La-binding protein 1) (Rab4-interacting protein) (Zinc finger FYVE domain-containing protein 12)
1_MADRE 6_ GGCAA 11_ GRGRE 16_ LEPEL 21_ EPGPG 26_ PGSAL 31_ EPGEE 36_ FEIVD 41_ RSQLP 46_ GPGDL 51_ RSATR 56_ PRAAE 61_ GWSAP 66_ ILTLA 71_ RRATG 76_ NLSAS 81_ CGSAL 86_ RAAAG 91_ LGGGD 96_ SGDGT 101_ ARAAS 106_ KCQMM 111_ EERAN 116_ LMHMM 121_ KLSIK 126_ VLLQS 131_ ALSLG 136_ RSLDA 141_ DHAPL 146_ QQFFV 151_ VMEHC 156_ LKHGL 161_ KVKKS 166_ FIGQN 171_ KSFFG 176_ PLELV 181_ EKLCP 186_ EASDI 191_ ATSVR 196_ NLPEL 201_ KTAVG 206_ RGRAW 211_ LYLAL 216_ MQKKL 221_ ADYLK 226_ VLIDN 231_ KHLLS 236_ EFYEP 241_ EALMM 246_ EEEGM 251_ VIVGL 256_ LVGLN 261_ VLDAN 266_ LCLKG 271_ EDLDS 276_ QVGVI 281_ DFSLY 286_ LKDVQ 291_ DLDGG 296_ KEHER 301_ ITDVL 306_ DQKNY 311_ VEELN 316_ RHLSC 321_ TVGDL 326_ QTKID 331_ GLEKT 336_ NSKLQ 341_ EELSA 346_ ATDRI 351_ CSLQE 356_ EQQQL 361_ REQNE 366_ LIRER 371_ SEKSV 376_ EITKQ 381_ DTKVE 386_ LETYK 391_ QTRQG 396_ LDEMY 401_ SDVWK 406_ QLKEE 411_ KKVRL 416_ ELEKE 421_ LELQI 426_ GMKTE 431_ MEIAM 436_ KLLEK 441_ DTHEK 446_ QDTLV 451_ ALRQQ 456_ LEEVK 461_ AINLQ 466_ MFHKA 471_ QNAES 476_ SLQQK 481_ NEAIT 486_ SFEGK 491_ TNQVM 496_ SSMKQ 501_ MEERL 506_ QHSER 511_ ARQGA 516_ EERSH 521_ KLQQE 526_ LGGRI 531_ GALQL 536_ QLSQL 541_ HEQCS 546_ SLEKE 551_ LKSEK 556_ EQRQA 561_ LQREL 566_ QHEKD 571_ TSSLL 576_ RMELQ 581_ QVEGL 586_ KKELR 591_ ELQDE 596_ KAELQ 601_ KICEE 606_ QEQAL 611_ QEMGL 616_ HLSQS 621_ KLKME 626_ DIKEV 631_ NQALK 636_ GHAWL 641_ KDDEA 646_ THCRQ 651_ CEKEF 656_ SISRR 661_ KHHCR 666_ NCGHI 671_ FCNTC 676_ SSNEL 681_ ALPSY 686_ PKPVR 691_ VCDSC 696_ HTLLL 701_QRCSS
1: Activating adapter involved in cargo sorting from early/recycling endosomes. Regulates retrieval of proteins from endosomes to the trans-Golgi network through interaction with the dynein-dynactin complex (PubMed:36282215). Dual effector of RAB4B and RAB14, mediates a cooperative interaction allowing endosomal tethering and fusion (PubMed:20534812). Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking (PubMed:14617813). In oocytes, self-assembles to form a protein matrix which hold together endolysosomes, autophagosomes and proteasomes and generate non-membrane-bound compartments called endo-lysosomal vesicular assemblies (ELVAs). In immature oocytes, ELVAs sequester ubiquitinated protein aggregates and degrade them upon oocyte maturation (By similarity)