Ghrelin O-acyltransferase (EC 2.3.1.-) (Membrane-bound O-acyltransferase domain-containing protein 4) (O-acyltransferase domain-containing protein 4)
1_MEWLW 6_ LFFLH 11_ PISFY 16_ QGAAF 21_ PFALL 26_ FNYLC 31_ IMDSF 36_ STRAR 41_ YLFLL 46_ TGGGA 51_ LAVAA 56_ MGSYA 61_ VLVFT 66_ PAVCA 71_ VALLC 76_ SLAPQ 81_ QVHRW 86_ TFCFQ 91_ MSWQT 96_ LCHLG 101_ LHYTE 106_ YYLHE 111_ PPSVR 116_ FCITL 121_ SSLML 126_ LTQRV 131_ TSLSL 136_ DICEG 141_ KVKAA 146_ SGGFR 151_ SRSSL 156_ SEHVC 161_ KALPY 166_ FSYLL 171_ FFPAL 176_ LGGSL 181_ CSFQR 186_ FQARV 191_ QGSSA 196_ LHPRH 201_ SFWAL 206_ SWRGL 211_ QILGL 216_ ECLNV 221_ AVSRV 226_ VDAGA 231_ GLTDC 236_ QQFEC 241_ IYVVW 246_ TTAGL 251_ FKLTY 256_ YSHWI 261_ LDDSL 266_ LHAAG 271_ FGPEL 276_ GQSPG 281_ EEGYV 286_ PDADI 291_ WTLER 296_ THRIS 301_ VFSRK 306_ WNQST 311_ ARWLR 316_ RLVFQ 321_ HSRAW 326_ PLLQT 331_ FAFSA 336_ WWHGL 341_ HPGQV 346_ FGFVC 351_ WAVMV 356_ EADYL 361_ IHSFA 366_ NEFIR 371_ SWPMR 376_ LFYRT 381_ LTWAH 386_ TQLII 391_ AYIML 396_ AVEVR 401_ SLSSL 406_ WLLCN 411_ SYNSV 416_ FPMVY 421_ CILLL 426_LLAKR
1: Catalyzes ghrelin acylation at 'Ser-3' using preferentially octanoyl-CoA, hexanoyl-CoA and decanoyl-CoA as acyl-CoA donors leading to ghrelin activity (PubMed:18443287, PubMed:24045953, PubMed:25562443, PubMed:28134508). In vitro also uses acyl-CoA donors of different lengths from short-chain (C2) to long-chain fatty acids (C16) knowing that acyl-CoA donors from butanoyl-CoA (C4) to dodecanoyl-CoA (C12) are more efficient compared to longer acyl-CoA donors, such as myristoyl-CoA (C14) and palmitoyl-CoA (C16) that are not efficient (PubMed:18443287)