Potassium channel subfamily K member 16 (2P domain potassium channel Talk-1) (TWIK-related alkaline pH-activated K(+) channel 1) (TALK-1)
1_MPSAG 6_ LCSCW 11_ GGRVL 16_ PLLLA 21_ YVCYL 26_ LLGAT 31_ IFQLL 36_ ERQAE 41_ AQSRD 46_ QFQLE 51_ KLRFL 56_ ENYTC 61_ LDQWA 66_ MEQFV 71_ QVIME 76_ AWVKG 81_ VNPKG 86_ NSTNP 91_ SNWDF 96_ GSSFF 101_ FAGTV 106_ VTTIG 111_ YGNLA 116_ PSTEA 121_ GQVFC 126_ VFYAL 131_ LGIPL 136_ NVIFL 141_ NHLGT 146_ GLRAH 151_ LAAIE 156_ RWEDR 161_ PRRSQ 166_ VLQVL 171_ GLALF 176_ LTLGT 181_ LVILI 186_ FPPMV 191_ FSHVE 196_ GWSFS 201_ EGFYF 206_ AFITL 211_ STIGF 216_ GDYVV 221_ GTDPS 226_ KHYIS 231_ VYRSL 236_ AAIWI 241_ LLGLA 246_ WLALI 251_ LPLGP 256_ LLLHR 261_ CCQLW 266_ LLSLR 271_ QGCGA 276_ KAAPG 281_ RRPRR 286_ GSTAA 291_ RGVQV 296_ TPQDF 301_PISKK
1: K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate (PubMed:11263999, PubMed:12724142, PubMed:14985088, PubMed:26919430, PubMed:28928238, PubMed:34032641, PubMed:36063992). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:36063992). In pancreatic islets, conducts K(+) countercurrents for Ca(2+) release from the endoplasmic reticulum (ER) and regulates the frequency and duration of cytosolic Ca(2+) oscillations coupled to secretion of pancreatic hormones (PubMed:26239056, PubMed:28928238, PubMed:29402588, PubMed:34032641). In pancreatic beta cells, drives ER Ca(2+) efflux, which in turn activates Ca(2+)-dependent plasma membrane K(+) slow currents and cytosolic Ca(2+) influx, overall contributing to synchronous cytosolic Ca(2+) oscillations. Limits glucose-induced cytosolic Ca(2+) oscillations coupled to second-phase INS secretion (PubMed:26239056, PubMed:28928238, PubMed:34032641). Contributes to beta cell adaptation to acute inflammation by maintaining normal cytosolic Ca(2+) levels and INS secretion (By similarity). May regulate beta cell mitochondrial Ca(2+) levels either indirectly via ER Ca(2+) efflux or directly by hyperpolarizing the mitochondrial membrane potential. Limits mitochondrial Ca(2+) oscillations and ATP production involved in glucose homeostasis upon metabolic stress (By similarity). In pancreatic delta cells, limits Ca(2+)-induced Ca(2+)-release involved in somatostatin secretion and modulates islet paracrine signaling involved in glucagon secretion (PubMed:29402588). Permeable to other monovalent cations such as Rb(+) and Cs(+) (By similarity) (PubMed:26919430)