Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog)
1_MVRET 6_ RHLWV 11_ GNLPE 16_ NVREE 21_ KIIEH 26_ FKRYG 31_ RVESV 36_ KILPK 41_ RGSEG 46_ GVAAF 51_ VDFVD 56_ IKSAQ 61_ KAHNS 66_ VNKMG 71_ DRDLR 76_ TDYNE 81_ PGTIP 86_ SAARG 91_ LDDTV 96_ SIASR 101_ SREVS 106_ GFRGG 111_ GGGPA 116_ YGPPP 121_ SLHAR 126_ EGRYE 131_ RRLDG 136_ ASDNR 141_ ERAYE 146_ HSAYG 151_ HHERG 156_ TGGFD 161_ RTRHY 166_ DQDYY 171_ RDPRE 176_ RTLQH 181_ GLYYA 186_ SRSRS 191_ PNRFD 196_ AHDPR 201_ YEPRA 206_ REQFT 211_ LPSVV 216_ HRDIY 221_ RDDIT 226_ REVRG 231_ RRPER 236_ NYQHS 241_ RSRSP 246_ HSSQS 251_ RNQSP 256_ QRLAS 261_ QASRP 266_ TRSPS 271_ GSGSR 276_ SRSSS 281_ SDSIS 286_ SSSST 291_ SSDSS 296_ DSSSS 301_ SSDDS 306_ PARSV 311_ QSAAV 316_ PAPTS 321_ QLLSS 326_ LEKDE 331_ PRKSF 336_ GIKVQ 341_ NLPVR 346_ STDTS 351_ LKDGL 356_ FHEFK 361_ KFGKV 366_ TSVQI 371_ HGTSE 376_ ERYGL 381_ VFFRQ 386_ QEDQE 391_ KALTA 396_ SKGKL 401_ FFGMQ 406_ IEVTA 411_ WIGPE 416_ TESEN 421_ EFRPL 426_ DERID 431_ EFHPK 436_ ATRTL 441_ FIGNL 446_ EKTTT 451_ YHDLR 456_ NIFQR 461_ FGEIV 466_ DIDIK 471_ KVNGV 476_ PQYAF 481_ LQYCD 486_ IASVC 491_ KAIKK 496_ MDGEY 501_ LGNNR 506_ LKLGF 511_ GKSMP 516_ TNCVW 521_ LDGLS 526_ SNVSD 531_ QYLTR 536_ HFCRY 541_ GPVVK 546_ VVFDR 551_ LKGMA 556_ LVLYN 561_ EIEYA 566_ QAAVK 571_ ETKGR 576_ KIGGN 581_ KIKVD 586_ FANRE 591_ SQLAF 596_ YHCME 601_ KSGQD 606_ IRDFY 611_ EMLAE 616_ RREER 621_ RASYD 626_ YNQDR 631_ TYYES 636_ VRTPG 641_ TYPED 646_ SRRDY 651_ PARGR 656_ EFYSE 661_ WETYQ 666_ GDYYE 671_ SRYYD 676_ DPREY 681_ RDYRN 686_ DPYEQ 691_ DIREY 696_ SYRQR 701_ ERERE 706_ RERFE 711_ SDRDR 716_ DHERR 721_ PIERS 726_ QSPVH 731_ LRRPQ 736_ SPGAS 741_ PSQAE 746_ RLPSD 751_ SERRL 756_ YSRSS 761_ DRSGS 766_ CSSLS 771_ PPRYE 776_ KLDKS 781_ RLERY 786_ TKNEK 791_ TDKER 796_ TFDPE 801_ RVERE 806_ RRLIR 811_ KEKVE 816_ KDKTD 821_ KQKRK 826_ GKVHS 831_ PSSQS 836_ SETDQ 841_ ENERE 846_ QSPEK 851_ PRSCN 856_ KLSRE 861_ KADKE 866_ GIAKN 871_ RLELM 876_ PCVVL 881_ TRVKE 886_ KEGKV 891_ IDHTP 896_ VEKLK 901_ AKLDN 906_ DTVKS 911_ SALDQ 916_ KLQVS 921_ QTEPA 926_ KSDLS 931_ KLESV 936_ RMKVP 941_ KEKGL 946_ SSHVE 951_ VVEKE 956_ GRLKA 961_ RKHLK 966_ PEQPA 971_ DGVSA 976_ VDLEK 981_ LEARK 986_ RRFAD 991_ SNLKA 996_ EKQKP 1001_ EVKKS 1006_ SPEME 1011_ DARVL 1016_ SKKQP 1021_ DVSSR 1026_ EVILL 1031_ REGEA 1036_ ERKPV 1041_ RKEIL 1046_ KRESK 1051_ KIKLD 1056_ RLNTV 1061_ ASPKD 1066_ CQELA 1071_ SISVG 1076_ SGSRP 1081_ SSDLQ 1086_ ARLGE 1091_ LAGES 1096_ VENQE 1101_ VQSKK 1106_ PIPSK 1111_ PQLKQ 1116_ LQVLD 1121_ DQGPE 1126_ REDVR 1131_ KNYCS 1136_ LRDET 1141_ PERKS 1146_ GQEKS 1151_ HSVNT 1156_ EEKIG 1161_ IDIDH 1166_ TQSYR 1171_ KQMEQ 1176_ SRRKQ 1181_ QMEME 1186_ IAKSE 1191_ KFGSP 1196_ KKDVD 1201_ EYERR 1206_ SLVHE 1211_ VGKPP 1216_ QDVTD 1221_ DSPPS 1226_ KKKRM 1231_ DHVDF 1236_ DICTK 1241_ RERNY 1246_ RSSRQ 1251_ ISEDS 1256_ ERTGG 1261_ SPSVR 1266_ HGSFH 1271_ EDEDP 1276_ IGSPR 1281_ LLSVK 1286_ GSPKV 1291_ DEKVL 1296_ PYSNI 1301_ TVREE 1306_ SLKFN 1311_ PYDSS 1316_ RREQM 1321_ ADMAK 1326_ IKLSV 1331_ LNSED 1336_ ELNRW 1341_ DSQMK 1346_ QDAGR 1351_ FDVSF 1356_ PNSII 1361_ KRDSL 1366_ RKRSV 1371_ RDLEP 1376_ GEVPS 1381_ DSDED 1386_ GEHKS 1391_ HSPRA 1396_ SALYE 1401_ SSRLS 1406_ FLLRD 1411_ REDKL 1416_ RERDE 1421_ RLSSS 1426_ LERNK 1431_ FYSFA 1436_ LDKTI 1441_ TPDTK 1446_ ALLER 1451_ AKSLS 1456_ SSREE 1461_ NWSFL 1466_ DWDSR 1471_ FANFR 1476_ NNKDK 1481_ EKVDS 1486_ APRPI 1491_ PSWYM 1496_ KKKKI 1501_ RTDSE 1506_ GKMDD 1511_ KKEDH 1516_ KEEEQ 1521_ ERQEL 1526_ FASRF 1531_ LHSSI 1536_ FEQDS 1541_ KRLQH 1546_ LERKE 1551_ EDSDF 1556_ ISGRI 1561_ YGKQT 1566_ SEGAN 1571_ STTDS 1576_ IQEPV 1581_ VLFHS 1586_ RFMEL 1591_ TRMQQ 1596_ KEKEK 1601_ DQKPK 1606_ EVEKQ 1611_ EDTEN 1616_ HPKTP 1621_ ESAPE 1626_ NKDSE 1631_ LKTPP 1636_ SVGPP 1641_ SVTVV 1646_ TLESA 1651_ PSALE 1656_ KTTGD 1661_ KTVEA 1666_ PLVTE 1671_ EKTVE 1676_ PATVS 1681_ EEAKP 1686_ ASEPA 1691_ PAPVE 1696_ QLEQV 1701_ DLPPG 1706_ ADPDK 1711_ EAAMM 1716_ PAGVE 1721_ EGSSG 1726_ DQPPY 1731_ LDAKP 1736_ PTPGA 1741_ SFSQA 1746_ ESNVD 1751_ PEPDS 1756_ TQPLS 1761_ KPAQK 1766_ SEEAN 1771_ EPKAE 1776_ KPDAT 1781_ ADAEP 1786_ DANQK 1791_ AEAAP 1796_ ESQPP 1801_ ASEDL 1806_ EVDPP 1811_ VAAKD 1816_ KKPNK 1821_ SKRSK 1826_ TPVQA 1831_ AAVSI 1836_ VEKPV 1841_ TRKSE 1846_ RIDRE 1851_ KLKRS 1856_ NSPRG 1861_ EAQKL 1866_ LELKM 1871_ EAEKI 1876_ TRTAS 1881_ KNSAA 1886_ DLEHP 1891_ EPSLP 1896_ LSRTR 1901_ RRNVR 1906_ SVYAT 1911_ MGDHE 1916_ NRSPV 1921_ KEPVE 1926_ QPRVT 1931_ RKRLE 1936_ RELQE 1941_ AAAVP 1946_ TTPRR 1951_ GRPPK 1956_ TRRRA 1961_ DEEEE 1966_ NEAKE 1971_ PAETL 1976_ KPPEG 1981_ WRSPR 1986_ SQKTA 1991_ AGGGP 1996_ QGKKG 2001_ KNEPK 2006_ VDATR 2011_ PEATT 2016_ EVGPQ 2021_ IGVKE 2026_ SSMEP 2031_ KAAEE 2036_ EAGSE 2041_ QKRDR 2046_ KDAGT 2051_ DKNPP 2056_ ETAPV 2061_ EVVEK 2066_ KPAPE 2071_ KNSKS 2076_ KRGRS 2081_ RNSRL 2086_ AVDKS 2091_ ASLKN 2096_ VDAAV 2101_ SPRGA 2106_ AAQAG 2111_ ERESG 2116_ VVAVS 2121_ PEKSE 2126_ SPQKE 2131_ DGLSS 2136_ QLKSD 2141_ PVDPD 2146_ KEPEK 2151_ EDVSA 2156_ SGPSP 2161_ EATQL 2166_ AKQME 2171_ LEQAV 2176_ EHIAK 2181_ LAEAS 2186_ ASAAY 2191_ KADAP 2196_ EGLAP 2201_ EDRDK 2206_ PAHQA 2211_ SETEL 2216_ AAAIG 2221_ SIIND 2226_ ISGEP 2231_ ENFPA 2236_ PPPYP 2241_ GESQT 2246_ DLQPP 2251_ AGAQA 2256_ LQPSE 2261_ EGMET 2266_ DEAVS 2271_ GILET 2276_ EAATE 2281_ SSRPP 2286_ VNAPD 2291_ PSAGP 2296_ TDTKE 2301_ ARGNS 2306_ SETSH 2311_ SVPEA 2316_ KGSKE 2321_ VEVTL 2326_ VRKDK 2331_ GRQKT 2336_ TRSRR 2341_ KRNTN 2346_ KKVVA 2351_ PVESH 2356_ VPESN 2361_ QAQGE 2366_ SPAAN 2371_ EGTTV 2376_ QHPEA 2381_ PQEEK 2386_ QSEKP 2391_ HSTPP 2396_ QSCTS 2401_ DLSKI 2406_ PSTEN 2411_ SSQEI 2416_ SVEER 2421_ TPTKA 2426_ SVPPD 2431_ LPPPP 2436_ QPAPV 2441_ DEEPQ 2446_ ARFRV 2451_ HSIIE 2456_ SDPVT 2461_ PPSDP 2466_ SIPIP 2471_ TLPSV 2476_ TAAKL 2481_ SPPVA 2486_ SGGIP 2491_ HQSPP 2496_ TKVTE 2501_ WITRQ 2506_ EEPRA 2511_ QSTPS 2516_ PALPP 2521_ DTKAS 2526_ DVDTS 2531_ SSTLR 2536_ KILMD 2541_ PKYVS 2546_ ATSVT 2551_ STSVT 2556_ TAIAE 2561_ PVSAA 2566_ PCLHE 2571_ APPPP 2576_ VDSKK 2581_ PLEEK 2586_ TAPPV 2591_ TNNSE 2596_ IQASE 2601_ VLVAA 2606_ DKEKV 2611_ APVIA 2616_ PKITS 2621_ VISRM 2626_ PVSID 2631_ LENSQ 2636_ KITLA 2641_ KPAPQ 2646_ TLTGL 2651_ VSALT 2656_ GLVNV 2661_ SLVPV 2666_ NALKG 2671_ PVKGS 2676_ VTTLK 2681_ SLVST 2686_ PAGPV 2691_ NVLKG 2696_ PVNVL 2701_ TGPVN 2706_ VLTTP 2711_ VNATV 2716_ GTVNA 2721_ APGTV 2726_ NAAAS 2731_ AVNAT 2736_ ASAVT 2741_ VTAGA 2746_ VTAAS 2751_ GGVTA 2756_ TTGTV 2761_ TMAGA 2766_ VIAPS 2771_ TKCKQ 2776_ RASAN 2781_ ENSRF 2786_ HPGSM 2791_ PVIDD 2796_ RPADA 2801_ GSGAG 2806_ LRVNT 2811_ SEGVV 2816_ LLSYS 2821_ GQKTE 2826_ GPQRI 2831_ SAKIS 2836_ QIPPA 2841_ SAMDI 2846_ EFQQS 2851_ VSKSQ 2856_ VKPDS 2861_ VTASQ 2866_ PPSKG 2871_ PQAPA 2876_ GYANV 2881_ ATHST 2886_ LVLTA 2891_ QTYNA 2896_ SPVIS 2901_ SVKAD 2906_ RPSLE 2911_ KPEPI 2916_ HLSVS 2921_ TPVTQ 2926_ GGTVK 2931_ VLTQG 2936_ INTPP 2941_ VLVHN 2946_ QLVLT 2951_ PSIVT 2956_ TNKKL 2961_ ADPVT 2966_ LKIET 2971_ KVLQP 2976_ ANLGS 2981_ TLTPH 2986_ HPPAL 2991_ PSKLP 2996_ TEVNH 3001_ VPSGP 3006_ SIPAD 3011_ RTVSH 3016_ LAAAK 3021_ LDAHS 3026_ PRPSG 3031_ PGPSS 3036_ FPRAS 3041_ HPSST 3046_ ASTAL 3051_ STNAT 3056_ VMLAA 3061_ GIPVP 3066_ QFISS 3071_ IHPEQ 3076_ SVIMP 3081_ PHSIT 3086_ QTVSL 3091_ SHLSQ 3096_ GEVRM 3101_ NTPTL 3106_ PSITY 3111_ SIRPE 3116_ ALHSP 3121_ RAPLQ 3126_ PQQIE 3131_ VRAPQ 3136_ RASTP 3141_ QPAPA 3146_ GVPAL 3151_ ASQHP 3156_ PEEEV 3161_ HYHLP 3166_ VARAT 3171_ APVQS 3176_ EVLVM 3181_ QSEYR 3186_ LHPYT 3191_ VPRDV 3196_ RIMVH 3201_ PHVTA 3206_ VSEQP 3211_ RAADG 3216_ VVKVP 3221_ PASKA 3226_ PQQPG 3231_ KEAAK 3236_ TPDAK 3241_ AAPTP 3246_ TPAPV 3251_ PVPVP 3256_ LPAPA 3261_ PAPHG 3266_ EARIL 3271_ TVTPS 3276_ NQLQG 3281_ LPLTP 3286_ PVVVT 3291_ HGVQI 3296_ VHSSG 3301_ ELFQE 3306_ YRYGD 3311_ IRTYH 3316_ PPAQL 3321_ THTQF 3326_ PAASS 3331_ VGLPS 3336_ RTKTA 3341_ AQGPP 3346_ PEGEP 3351_ LQPPQ 3356_ PVQST 3361_ QPAQP 3366_ APPCP 3371_ PSQLG 3376_ QPGQP 3381_ PSSKM 3386_ PQVSQ 3391_ EAKGT 3396_ QTGVE 3401_ QPRLP 3406_ AGPAN 3411_ RPPEP 3416_ HTQVQ 3421_ RAQAE 3426_ TGPTS 3431_ FPSPV 3436_ SVSMK 3441_ PDLPV 3446_ SLPTQ 3451_ TAPKQ 3456_ PLFVP 3461_ TTSGP 3466_ STPPG 3471_ LVLPH 3476_ TEFQP 3481_ APKQD 3486_ SSPHL 3491_ TSQRP 3496_ VDMVQ 3501_ LLKKY 3506_ PIVWQ 3511_ GLLAL 3516_ KNDTA 3521_ AVQLH 3526_ FVSGN 3531_ NVLAH 3536_ RSLPL 3541_ SEGGP 3546_ PLRIA 3551_ QRMRL 3556_ EATQL 3561_ EGVAR 3566_ RMTVE 3571_ TDYCL 3576_ LLALP 3581_ CGRDQ 3586_ EDVVS 3591_ QTESL 3596_ KAAFI 3601_ TYLQA 3606_ KQAAG 3611_ IINVP 3616_ NPGSN 3621_ QPAYV 3626_ LQIFP 3631_ PCEFS 3636_ ESHLS 3641_ RLAPD 3646_ LLASI 3651_ SNISP 3656_HLMIV
1: May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA