Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)]
1_MGEVE 6_ APGRL 11_ WLESP 16_ PGGAP 21_ PIFLP 26_ SDGQA 31_ LVLGR 36_ GPLTQ 41_ VTDRK 46_ CSRTQ 51_ VELVA 56_ DPETR 61_ TVAVK 66_ QLGVN 71_ PSTTG 76_ TQELK 81_ PGLEG 86_ SLGVG 91_ DTLYL 96_ VNGLH 101_ PLTLR 106_ WEETR 111_ TPESQ 116_ PDTPP 121_ GTPLV 126_ SQDEK 131_ RDAEL 136_ PKKRM 141_ RKSNP 146_ GWENL 151_ EKLLV 156_ FTAAG 161_ VKPQG 166_ KVAGF 171_ DLDGT 176_ LITTR 181_ SGKVF 186_ PTGPS 191_ DWRIL 196_ YPEIP 201_ RKLRE 206_ LEAEG 211_ YKLVI 216_ FTNQM 221_ SIGRG 226_ KLPAE 231_ EFKAK 236_ VEAVV 241_ EKLGV 246_ PFQVL 251_ VATHA 256_ GLYRK 261_ PVTGM 266_ WDHLQ 271_ EQAND 276_ GTPIS 281_ IGDSI 286_ FVGDA 291_ AGRPA 296_ NWAPG 301_ RKKKD 306_ FSCAD 311_ RLFAL 316_ NLGLP 321_ FATPE 326_ EFFLK 331_ WPAAG 336_ FELPA 341_ FDPRT 346_ VSRSG 351_ PLCLP 356_ ESRAL 361_ LSASP 366_ EVVVA 371_ VGFPG 376_ AGKST 381_ FLKKH 386_ LVSAG 391_ YVHVN 396_ RDTLG 401_ SWQRC 406_ VTTCE 411_ TALKQ 416_ GKRVA 421_ IDNTN 426_ PDAAS 431_ RARYV 436_ QCARA 441_ AGVPC 446_ RCFLF 451_ TATLE 456_ QARHN 461_ NRFRE 466_ MTDSS 471_ HIPVS 476_ DMVMY 481_ GYRKQ 486_ FEAPT 491_ LAEGF 496_ SAILE 501_ IPFRL 506_ WVEPR 511_ LGRLY 516_CQFSE
1: Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways (PubMed:10446192, PubMed:10446193, PubMed:15385968, PubMed:20852255, PubMed:28453785). Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone (PubMed:10446192, PubMed:10446193)