Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 (NMN/NaMN adenylyltransferase 3) (Nicotinamide-nucleotide adenylyltransferase 3) (NMN adenylyltransferase 3) (Nicotinate-nucleotide adenylyltransferase 3) (NaMN adenylyltransferase 3) (EC 2.7.7.18) (Pyridine nucleotide adenylyltransferase 3) (PNAT-3) (EC 2.7.7.1)
1_MKSRI 6_ PVVLL 11_ ACGSF 16_ NPITN 21_ MHLRM 26_ FEVAR 31_ DHLHQ 36_ TGMYQ 41_ VIQGI 46_ ISPVN 51_ DTYGK 56_ KDLAA 61_ SHHRV 66_ AMARL 71_ ALQTS 76_ DWIRV 81_ DPWES 86_ EQAQW 91_ METVK 96_ VLRHH 101_ HSKLL 106_ RSPPQ 111_ MEGPD 116_ HGKAL 121_ FSTPA 126_ AVPEL 131_ KLLCG 136_ ADVLK 141_ TFQTP 146_ NLWKD 151_ AHIQE 156_ IVEKF 161_ GLVCV 166_ GRVGH 171_ DPKGY 176_ IAESP 181_ ILRMH 186_ QHNIH 191_ LAKEP 196_ VQNEI 201_ SATYI 206_ RRALG 211_ QGQSV 216_ KYLIP 221_ DAVIT 226_ YIKDH 231_ GLYTK 236_ GSTWK 241_ GKSTQ 246_STEGK
1: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:16118205, PubMed:17402747, PubMed:26616331). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury (PubMed:16118205, PubMed:17402747). May be involved in the maintenance of axonal integrity (By similarity). Also functions as a stress-response chaperone protein that prevents toxic aggregation of proteins; this function may be independent of its NAD(+) synthesis activity (PubMed:18344983)