Histone-lysine N-methyltransferase SETDB2 (EC 2.1.1.366) (Chronic lymphocytic leukemia deletion region gene 8 protein) (Lysine N-methyltransferase 1F) (SET domain bifurcated 2)
1_MGEKN 6_ GDAKT 11_ FWMEL 16_ EDDGK 21_ VDFIF 26_ EQVQN 31_ VLQSL 36_ KQKIK 41_ DGSAT 46_ NKEYI 51_ QAMIL 56_ VNEAT 61_ IINSS 66_ TSIKG 71_ ASQKE 76_ VNAQS 81_ SDPMP 86_ VTQKE 91_ QENKS 96_ NAFPS 101_ TSCEN 106_ SFPED 111_ CTFLT 116_ TENKE 121_ ILSLE 126_ DKVVD 131_ FREKD 136_ SSSNL 141_ SYQSH 146_ DCSGA 151_ CLMKM 156_ PLNLK 161_ GENPL 166_ QLPIK 171_ CHFQR 176_ RHAKT 181_ NSHSS 186_ ALHVS 191_ YKTPC 196_ GRSLR 201_ NVEEV 206_ FRYLL 211_ ETECN 216_ FLFTD 221_ NFSFN 226_ TYVQL 231_ ARNYP 236_ KQKEV 241_ VSDVD 246_ ISNGV 251_ ESVPI 256_ SFCNE 261_ IDSRK 266_ LPQFK 271_ YRKTV 276_ WPRAY 281_ NLTNF 286_ SSMFT 291_ DSCDC 296_ SEGCI 301_ DITKC 306_ ACLQL 311_ TARNA 316_ KTSPL 321_ SSDKI 326_ TTGYK 331_ YKRLQ 336_ RQIPT 341_ GIYEC 346_ SLLCK 351_ CNRQL 356_ CQNRV 361_ VQHGP 366_ QVRLQ 371_ VFKTE 376_ QKGWG 381_ VRCLD 386_ DIDRG 391_ TFVCI 396_ YSGRL 401_ LSRAN 406_ TEKSY 411_ GIDEN 416_ GRDEN 421_ TMKNI 426_ FSKKR 431_ KLEVA 436_ CSDCE 441_ VEVLP 446_ LGLET 451_ HPRTA 456_ KTEKC 461_ PPKFS 466_ NNPKE 471_ LTVET 476_ KYDNI 481_ SRIQY 486_ HSVIR 491_ DPESK 496_ TAIFQ 501_ HNGKK 506_ MEFVS 511_ SESVT 516_ PEDND 521_ GFKPP 526_ REHLN 531_ SKTKG 536_ AQKDS 541_ SSNHV 546_ DEFED 551_ NLLIE 556_ SDVID 561_ ITKYR 566_ EETPP 571_ RSRCN 576_ QATTL 581_ DNQNI 586_ KKAIE 591_ VQIQK 596_ PQEGR 601_ STACQ 606_ RQQVF 611_ CDEEL 616_ LSETK 621_ NTSSD 626_ SLTKF 631_ NKGNV 636_ FLLDA 641_ TKEGN 646_ VGRFL 651_ NHSCC 656_ PNLLV 661_ QNVFV 666_ ETHNR 671_ NFPLV 676_ AFFTN 681_ RYVKA 686_ RTELT 691_ WDYGY 696_ EAGTV 701_ PEKEI 706_ FCQCG 711_VNKCR
1: Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis