MMS19 nucleotide excision repair protein homolog (hMMS19) (MET18 homolog) (MMS19-like protein)
1_MAAAA 6_ AVEAA 11_ APMGA 16_ LWGLV 21_ HDFVV 26_ GQQEG 31_ PADQV 36_ AADVK 41_ SGNYT 46_ VLQVV 51_ EALGS 56_ SLENP 61_ EPRTR 66_ ARAIQ 71_ LLSQV 76_ LLHCH 81_ TLLLE 86_ KEVVH 91_ LILFY 96_ ENRLK 101_ DHHLV 106_ IPSVL 111_ QGLKA 116_ LSLCV 121_ ALPPG 126_ LAVSV 131_ LKAIF 136_ QEVHV 141_ QSLPQ 146_ VDRHT 151_ VYNII 156_ TNFMR 161_ TREEE 166_ LKSLG 171_ ADFTF 176_ GFIQV 181_ MDGEK 186_ DPRNL 191_ LVAFR 196_ IVHDL 201_ ISRDY 206_ SLGPF 211_ VEELF 216_ EVTSC 221_ YFPID 226_ FTPPP 231_ NDPHG 236_ IQRED 241_ LILSL 246_ RAVLA 251_ STPRF 256_ AEFLL 261_ PLLIE 266_ KVDSE 271_ VLSAK 276_ LDSLQ 281_ TLNAC 286_ CAVYG 291_ QKELK 296_ DFLPS 301_ LWASI 306_ RREVF 311_ QTASE 316_ RVEAE 321_ GLAAL 326_ HSLTA 331_ CLSRS 336_ VLRAD 341_ AEDLL 346_ DSFLS 351_ NILQD 356_ CRHHL 361_ CEPDM 366_ KLVWP 371_ SAKLL 376_ QAAAG 381_ ASARA 386_ CDSVT 391_ SNVLP 396_ LLLEQ 401_ FHKHS 406_ QSSQR 411_ RTILE 416_ MLLGF 421_ LKLQQ 426_ KWSYE 431_ DKDQR 436_ PLNGF 441_ KDQLC 446_ SLVFM 451_ ALTDP 456_ STQLQ 461_ LVGIR 466_ TLTVL 471_ GAQPD 476_ LLSYE 481_ DLELA 486_ VGHLY 491_ RLSFL 496_ KEDSQ 501_ SCRVA 506_ ALEAS 511_ GTLAA 516_ LYPVA 521_ FSSHL 526_ VPKLA 531_ EELRV 536_ GESNL 541_ TNGDE 546_ PTQCS 551_ RHLCC 556_ LQALS 561_ AVSTH 566_ PSIVK 571_ ETLPL 576_ LLQHL 581_ WQVNR 586_ GNMVA 591_ QSSDV 596_ IAVCQ 601_ SLRQM 606_ AEKCQ 611_ QDPES 616_ CWYFH 621_ QTAIP 626_ CLLAL 631_ AVQAS 636_ MPEKE 641_ PSVLR 646_ KVLLE 651_ DEVLA 656_ AMVSV 661_ IGTAT 666_ THLSP 671_ ELAAQ 676_ SVTHI 681_ VPLFL 686_ DGNVS 691_ FLPEN 696_ SFPSR 701_ FQPFQ 706_ DGSSG 711_ QRRLI 716_ ALLMA 721_ FVCSL 726_ PRNVE 731_ IPQLN 736_ QLMRE 741_ LLELS 746_ CCHSC 751_ PFSST 756_ AAAKC 761_ FAGLL 766_ NKHPA 771_ GQQLD 776_ EFLQL 781_ AVDKV 786_ EAGLG 791_ SGPCR 796_ SQAFT 801_ LLLWV 806_ TKALV 811_ LRYHP 816_ LSSCL 821_ TARLM 826_ GLLSD 831_ PELGP 836_ AAADG 841_ FSLLM 846_ SDCTD 851_ VLTRA 856_ GHAEV 861_ RIMFR 866_ QRFFT 871_ DNVPA 876_ LVQGF 881_ HAAPQ 886_ DVKPN 891_ YLKGL 896_ SHVLN 901_ RLPKP 906_ VLLPE 911_ LPTLL 916_ SLLLE 921_ ALSCP 926_ DCVVQ 931_ LSTLS 936_ CLQPL 941_ LLEAP 946_ QVMSL 951_ HVDTL 956_ VTKFL 961_ NLSSS 966_ PSMAV 971_ RIAAL 976_ QCMHA 981_ LTRLP 986_ TPVLL 991_ PYKPQ 996_ VIRAL 1001_ AKPLD 1006_ DKKRL 1011_ VRKEA 1016_ VSARG 1021_EWFLL
1: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity (PubMed:29848660). In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER), homologous recombination-mediated double-strand break DNA repair, DNA replication and RNA polymerase II (POL II) transcription (PubMed:22678361, PubMed:22678362, PubMed:23585563, PubMed:29225034). As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur (Fe-S) cluster assembly into ERCC2/XPD (PubMed:20797633). Together with CIAO2, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis (PubMed:29848660). Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery (PubMed:11279242)