E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)
1_MWIQV 6_ RTMDG 11_ RQTHT 16_ VDSLS 21_ RLTKV 26_ EELRR 31_ KIQEL 36_ FHVEP 41_ GLQRL 46_ FYRGK 51_ QMEDG 56_ HTLFD 61_ YEVRL 66_ NDTIQ 71_ LLVRQ 76_ SLVLP 81_ HSTKE 86_ RDSEL 91_ SDTDS 96_ GCCLG 101_ QSESD 106_ KSSTH 111_ GEAAA 116_ ETDSR 121_ PADED 126_ MWDET 131_ ELGLY 136_ KVNEY 141_ VDARD 146_ TNMGA 151_ WFEAQ 156_ VVRVT 161_ RKAPS 166_ RDEPC 171_ SSTSR 176_ PALEE 181_ DVIYH 186_ VKYDD 191_ YPENG 196_ VVQMN 201_ SRDVR 206_ ARART 211_ IIKWQ 216_ DLEVG 221_ QVVML 226_ NYNPD 231_ NPKER 236_ GFWYD 241_ AEISR 246_ KRETR 251_ TAREL 256_ YANVV 261_ LGDDS 266_ LNDCR 271_ IIFVD 276_ EVFKI 281_ ERPGE 286_ GSPMV 291_ DNPMR 296_ RKSGP 301_ SCKHC 306_ KDDVN 311_ RLCRV 316_ CACHL 321_ CGGRQ 326_ DPDKQ 331_ LMCDE 336_ CDMAF 341_ HIYCL 346_ DPPLS 351_ SVPSE 356_ DEWYC 361_ PECRN 366_ DASEV 371_ VLAGE 376_ RLRES 381_ KKKAK 386_ MASAT 391_ SSSQR 396_ DWGKG 401_ MACVG 406_ RTKEC 411_ TIVPS 416_ NHYGP 421_ IPGIP 426_ VGTMW 431_ RFRVQ 436_ VSESG 441_ VHRPH 446_ VAGIH 451_ GRSND 456_ GAYSL 461_ VLAGG 466_ YEDDV 471_ DHGNF 476_ FTYTG 481_ SGGRD 486_ LSGNK 491_ RTAEQ 496_ SCDQK 501_ LTNTN 506_ RALAL 511_ NCFAP 516_ INDQE 521_ GAEAK 526_ DWRSG 531_ KPVRV 536_ VRNVK 541_ GGKNS 546_ KYAPA 551_ EGNRY 556_ DGIYK 561_ VVKYW 566_ PEKGK 571_ SGFLV 576_ WRYLL 581_ RRDDD 586_ EPGPW 591_ TKEGK 596_ DRIKK 601_ LGLTM 606_ QYPEG 611_ YLEAL 616_ ANRER 621_ EKENS 626_ KREEE 631_ EQQEG 636_ GFASP 641_ RTGKG 646_ KWKRK 651_ SAGGG 656_ PSRAG 661_ SPRRT 666_ SKKTK 671_ VEPYS 676_ LTAQQ 681_ SSLIR 686_ EDKSN 691_ AKLWN 696_ EVLAS 701_ LKDRP 706_ ASGSP 711_ FQLFL 716_ SKVEE 721_ TFQCI 726_ CCQEL 731_ VFRPI 736_ TTVCQ 741_ HNVCK 746_ DCLDR 751_ SFRAQ 756_ VFSCP 761_ ACRYD 766_ LGRSY 771_ AMQVN 776_ QPLQT 781_ VLNQL 786_FPGYG
1: Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. Plays a role in DNA repair by cooperating with UHRF2 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation. Acts as a critical player of proper spindle architecture by catalyzing the 'Lys-63'-linked ubiquitination of KIF11, thereby controlling KIF11 localization on the spindle (PubMed:37728657)