Gene name: GPHA2

Uniprot entry:

Q96T91

Protein names:

Glycoprotein hormone alpha-2 (Putative secreted protein Zsig51) (Thyrostimulin subunit alpha)

Protein sequence:

1_MPMAS 6_ PQTLV 11_ LYLLV 16_ LAVTE 21_ AWGQE 26_ AVIPG 31_ CHLHP 36_ FNVTV 41_ RSDRQ 46_ GTCQG 51_ SHVAQ 56_ ACVGH 61_ CESSA 66_ FPSRY 71_ SVLVA 76_ SGYRH 81_ NITSV 86_ SQCCT 91_ ISGLK 96_ KVKVQ 101_ LQCVG 106_ SRREE 111_ LEIFT 116_ ARACQ 121_CDMCR

Protein annotations

Protein functions:

1: Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production (PubMed:12045258). Plays a central role in controlling thyroid cell metabolism (PubMed:12045258)