Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor (HB-EGF) (HBEGF) (Diphtheria toxin receptor) (DT-R)]
1_MKLLP 6_ SVVLK 11_ LFLAA 16_ VLSAL 21_ VTGES 26_ LERLR 31_ RGLAA 36_ GTSNP 41_ DPPTV 46_ STDQL 51_ LPLGG 56_ GRDRK 61_ VRDLQ 66_ EADLD 71_ LLRVT 76_ LSSKP 81_ QALAT 86_ PNKEE 91_ HGKRK 96_ KKGKG 101_ LGKKR 106_ DPCLR 111_ KYKDF 116_ CIHGE 121_ CKYVK 126_ ELRAP 131_ SCICH 136_ PGYHG 141_ ERCHG 146_ LSLPV 151_ ENRLY 156_ TYDHT 161_ TILAV 166_ VAVVL 171_ SSVCL 176_ LVIVG 181_ LLMFR 186_ YHRRG 191_ GYDVE 196_ NEEKV 201_KLGMT
1: Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor