Cytohesin-2 (ARF exchange factor) (ARF nucleotide-binding site opener) (Protein ARNO) (PH, SEC7 and coiled-coil domain-containing protein 2)
1_MEDGV 6_ YEPPD 11_ LTPEE 16_ RMELE 21_ NIRRR 26_ KQELL 31_ VEIQR 36_ LREEL 41_ SEAMS 46_ EVEGL 51_ EANEG 56_ SKTLQ 61_ RNRKM 66_ AMGRK 71_ KFNMD 76_ PKKGI 81_ QFLVE 86_ NELLQ 91_ NTPEE 96_ IARFL 101_ YKGEG 106_ LNKTA 111_ IGDYL 116_ GEREE 121_ LNLAV 126_ LHAFV 131_ DLHEF 136_ TDLNL 141_ VQALR 146_ QFLWS 151_ FRLPG 156_ EAQKI 161_ DRMME 166_ AFAQR 171_ YCLCN 176_ PGVFQ 181_ STDTC 186_ YVLSF 191_ AVIML 196_ NTSLH 201_ NPNVR 206_ DKPGL 211_ ERFVA 216_ MNRGI 221_ NEGGD 226_ LPEEL 231_ LRNLY 236_ DSIRN 241_ EPFKI 246_ PEDDG 251_ NDLTH 256_ TFFNP 261_ DREGW 266_ LLKLG 271_ GGRVK 276_ TWKRR 281_ WFILT 286_ DNCLY 291_ YFEYT 296_ TDKEP 301_ RGIIP 306_ LENLS 311_ IREVD 316_ DPRKP 321_ NCFEL 326_ YIPNN 331_ KGQLI 336_ KACKT 341_ EADGR 346_ VVEGN 351_ HMVYR 356_ ISAPT 361_ QEEKD 366_ EWIKS 371_ IQAAV 376_ SVDPF 381_ YEMLA 386_ ARKKR 391_ISVKK
1: Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similarity). The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (PubMed:17398095). Involved in neurite growth (By similarity)