Protein kinase C-binding protein NELL2 (NEL-like protein 2) (Nel-related protein 2)
1_MESRV 6_ LLRTF 11_ CLIFG 16_ LGAVW 21_ GLGVD 26_ PSLQI 31_ DVLTE 36_ LELGE 41_ STTGV 46_ RQVPG 51_ LHNGT 56_ KAFLF 61_ QDTPR 66_ SIKAS 71_ TATAE 76_ QFFQK 81_ LRNKH 86_ EFTIL 91_ VTLKQ 96_ THLNS 101_ GVILS 106_ IHHLD 111_ HRYLE 116_ LESSG 121_ HRNEV 126_ RLHYR 131_ SGSHR 136_ PHTEV 141_ FPYIL 146_ ADDKW 151_ HKLSL 156_ AISAS 161_ HLILH 166_ IDCNK 171_ IYERV 176_ VEKPS 181_ TDLPL 186_ GTTFW 191_ LGQRN 196_ NAHGY 201_ FKGIM 206_ QDVQL 211_ LVMPQ 216_ GFIAQ 221_ CPDLN 226_ RTCPT 231_ CNDFH 236_ GLVQK 241_ IMELQ 246_ DILAK 251_ TSAKL 256_ SRAEQ 261_ RMNRL 266_ DQCYC 271_ ERTCT 276_ MKGTT 281_ YREFE 286_ SWIDG 291_ CKNCT 296_ CLNGT 301_ IQCET 306_ LICPN 311_ PDCPL 316_ KSALA 321_ YVDGK 326_ CCKEC 331_ KSICQ 336_ FQGRT 341_ YFEGE 346_ RNTVY 351_ SSSGV 356_ CVLYE 361_ CKDQT 366_ MKLVE 371_ SSGCP 376_ ALDCP 381_ ESHQI 386_ TLSHS 391_ CCKVC 396_ KGYDF 401_ CSERH 406_ NCMEN 411_ SICRN 416_ LNDRA 421_ VCSCR 426_ DGFRA 431_ LREDN 436_ AYCED 441_ IDECA 446_ EGRHY 451_ CRENT 456_ MCVNT 461_ PGSFM 466_ CICKT 471_ GYIRI 476_ DDYSC 481_ TEHDE 486_ CITNQ 491_ HNCDE 496_ NALCF 501_ NTVGG 506_ HNCVC 511_ KPGYT 516_ GNGTT 521_ CKAFC 526_ KDGCR 531_ NGGAC 536_ IAANV 541_ CACPQ 546_ GFTGP 551_ SCETD 556_ IDECS 561_ DGFVQ 566_ CDSRA 571_ NCINL 576_ PGWYH 581_ CECRD 586_ GYHDN 591_ GMFSP 596_ SGESC 601_ EDIDE 606_ CGTGR 611_ HSCAN 616_ DTICF 621_ NLDGG 626_ YDCRC 631_ PHGKN 636_ CTGDC 641_ IHDGK 646_ VKHNG 651_ QIWVL 656_ ENDRC 661_ SVCSC 666_ QNGFV 671_ MCRRM 676_ VCDCE 681_ NPTVD 686_ LFCCP 691_ ECDPR 696_ LSSQC 701_ LHQNG 706_ ETLYN 711_ SGDTW 716_ VQNCQ 721_ QCRCL 726_ QGEVD 731_ CWPLP 736_ CPDVE 741_ CEFSI 746_ LPENE 751_ CCPRC 756_ VTDPC 761_ QADTI 766_ RNDIT 771_ KTCLD 776_ EMNVV 781_ RFTGS 786_ SWIKH 791_ GTECT 796_ LCQCK 801_ NGHIC 806_ CSVDP 811_QCLQE
1: Plays multiple roles in neural tissues, regulates neuronal proliferation, survival, differentiation, polarization, as well as axon guidance and synaptic functions. Plays an important role in axon development during neuronal differentiation through the MAPK intracellular signaling pathway (By similarity). Via binding to its receptor ROBO3, plays a role in axon guidance, functioning as a repulsive axon guidance cue that contributes to commissural axon guidance to the midline (PubMed:32198364). Required for neuron survival through the modulation of MAPK signaling pathways too. Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity)
2: Epididymal-secreted protein that signals through a ROS1-pathway to regulate the epididymal initial segment (IS) maturation, sperm maturation and male fertility