Proteasome subunit beta type-7 (EC 3.4.25.1) (Macropain chain Z) (Multicatalytic endopeptidase complex chain Z) (Proteasome subunit Z)
1_MAAVS 6_ VYAPP 11_ VGGFS 16_ FDNCR 21_ RNAVL 26_ EADFA 31_ KRGYK 36_ LPKVR 41_ KTGTT 46_ IAGVV 51_ YKDGI 56_ VLGAD 61_ TRATE 66_ GMVVA 71_ DKNCS 76_ KIHFI 81_ SPNIY 86_ CCGAG 91_ TAADT 96_ DMTTQ 101_ LISSN 106_ LELHS 111_ LSTGR 116_ LPRVV 121_ TANRM 126_ LKQML 131_ FRYQG 136_ YIGAA 141_ LVLGG 146_ VDVTG 151_ PHLYS 156_ IYPHG 161_ STDKL 166_ PYVTM 171_ GSGSL 176_ AAMAV 181_ FEDKF 186_ RPDME 191_ EEEAK 196_ NLVSE 201_ AIAAG 206_ IFNDL 211_ GSGSN 216_ IDLCV 221_ ISKNK 226_ LDFLR 231_ PYTVP 236_ NKKGT 241_ RLGRY 246_ RCEKG 251_ TTAVL 256_ TEKIT 261_ PLEIE 266_ VLEET 271_VQTMD
1: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity