Translocation protein SEC62 (Translocation protein 1) (TP-1) (hTP-1)
1_MAERR 6_ RHKKR 11_ IQEVG 16_ EPSKE 21_ EKAVA 26_ KYLRF 31_ NCPTK 36_ STNMM 41_ GHRVD 46_ YFIAS 51_ KAVDC 56_ LLDSK 61_ WAKAK 66_ KGEEA 71_ LFTTR 76_ ESVVD 81_ YCNRL 86_ LKKQF 91_ FHRAL 96_ KVMKM 101_ KYDKD 106_ IKKEK 111_ DKGKA 116_ ESGKE 121_ EDKKS 126_ KKENI 131_ KDEKT 136_ KKEKE 141_ KKKDG 146_ EKEES 151_ KKEET 156_ PGTPK 161_ KKETK 166_ KKFKL 171_ EPHDD 176_ QVFLD 181_ GNEVY 186_ VWIYD 191_ PVHFK 196_ TFVMG 201_ LILVI 206_ AVIAA 211_ TLFPL 216_ WPAEM 221_ RVGVY 226_ YLSVG 231_ AGCFV 236_ ASILL 241_ LAVAR 246_ CILFL 251_ IIWLI 256_ TGGRH 261_ HFWFL 266_ PNLTA 271_ DVGFI 276_ DSFRP 281_ LYTHE 286_ YKGPK 291_ ADLKK 296_ DEKSE 301_ TKKQQ 306_ KSDSE 311_ EKSDS 316_ EKKED 321_ EEGKV 326_ GPGNH 331_ GTEGS 336_ GGERH 341_ SDTDS 346_ DRRED 351_ DRSQH 356_ SSGNG 361_ NDFEM 366_ ITKEE 371_ LEQQT 376_ DGDCE 381_ EDEEE 386_ ENDGE 391_TPKSS
1: Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides. Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen