Neurogenic locus notch homolog protein 4 (Notch 4) (hNotch4) [Cleaved into: Notch 4 extracellular truncation; Notch 4 intracellular domain]
1_MQPPS 6_ LLLLL 11_ LLLLL 16_ LCVSV 21_ VRPRG 26_ LLCGS 31_ FPEPC 36_ ANGGT 41_ CLSLS 46_ LGQGT 51_ CQCAP 56_ GFLGE 61_ TCQFP 66_ DPCQN 71_ AQLCQ 76_ NGGSC 81_ QALLP 86_ APLGL 91_ PSSPS 96_ PLTPS 101_ FLCTC 106_ LPGFT 111_ GERCQ 116_ AKLED 121_ PCPPS 126_ FCSKR 131_ GRCHI 136_ QASGR 141_ PQCSC 146_ MPGWT 151_ GEQCQ 156_ LRDFC 161_ SANPC 166_ VNGGV 171_ CLATY 176_ PQIQC 181_ HCPPG 186_ FEGHA 191_ CERDV 196_ NECFQ 201_ DPGPC 206_ PKGTS 211_ CHNTL 216_ GSFQC 221_ LCPVG 226_ QEGPR 231_ CELRA 236_ GPCPP 241_ RGCSN 246_ GGTCQ 251_ LMPEK 256_ DSTFH 261_ LCLCP 266_ PGFIG 271_ PDCEV 276_ NPDNC 281_ VSHQC 286_ QNGGT 291_ CQDGL 296_ DTYTC 301_ LCPET 306_ WTGWD 311_ CSEDV 316_ DECET 321_ QGPPH 326_ CRNGG 331_ TCQNS 336_ AGSFH 341_ CVCVS 346_ GWGGT 351_ SCEEN 356_ LDDCI 361_ AATCA 366_ PGSTC 371_ IDRVG 376_ SFSCL 381_ CPPGR 386_ TGLLC 391_ HLEDM 396_ CLSQP 401_ CHGDA 406_ QCSTN 411_ PLTGS 416_ TLCLC 421_ QPGYS 426_ GPTCH 431_ QDLDE 436_ CLMAQ 441_ QGPSP 446_ CEHGG 451_ SCLNT 456_ PGSFN 461_ CLCPP 466_ GYTGS 471_ RCEAD 476_ HNECL 481_ SQPCH 486_ PGSTC 491_ LDLLA 496_ TFHCL 501_ CPPGL 506_ EGQLC 511_ EVETN 516_ ECASA 521_ PCLNH 526_ ADCHD 531_ LLNGF 536_ QCICL 541_ PGFSG 546_ TRCEE 551_ DIDEC 556_ RSSPC 561_ ANGGQ 566_ CQDQP 571_ GAFHC 576_ KCLPG 581_ FEGPR 586_ CQTEV 591_ DECLS 596_ DPCPV 601_ GASCL 606_ DLPGA 611_ FFCLC 616_ PSGFT 621_ GQLCE 626_ VPLCA 631_ PNLCQ 636_ PKQIC 641_ KDQKD 646_ KANCL 651_ CPDGS 656_ PGCAP 661_ PEDNC 666_ TCHHG 671_ HCQRS 676_ SCVCD 681_ VGWTG 686_ PECEA 691_ ELGGC 696_ ISAPC 701_ AHGGT 706_ CYPQP 711_ SGYNC 716_ TCPTG 721_ YTGPT 726_ CSEEM 731_ TACHS 736_ GPCLN 741_ GGSCN 746_ PSPGG 751_ YYCTC 756_ PPSHT 761_ GPQCQ 766_ TSTDY 771_ CVSAP 776_ CFNGG 781_ TCVNR 786_ PGTFS 791_ CLCAM 796_ GFQGP 801_ RCEGK 806_ LRPSC 811_ ADSPC 816_ RNRAT 821_ CQDSP 826_ QGPRC 831_ LCPTG 836_ YTGGS 841_ CQTLM 846_ DLCAQ 851_ KPCPR 856_ NSHCL 861_ QTGPS 866_ FHCLC 871_ LQGWT 876_ GPLCN 881_ LPLSS 886_ CQKAA 891_ LSQGI 896_ DVSSL 901_ CHNGG 906_ LCVDS 911_ GPSYF 916_ CHCPP 921_ GFQGS 926_ LCQDH 931_ VNPCE 936_ SRPCQ 941_ NGATC 946_ MAQPS 951_ GYLCQ 956_ CAPGY 961_ DGQNC 966_ SKELD 971_ ACQSQ 976_ PCHNH 981_ GTCTP 986_ KPGGF 991_ HCACP 996_ PGFVG 1001_ LRCEG 1006_ DVDEC 1011_ LDQPC 1016_ HPTGT 1021_ AACHS 1026_ LANAF 1031_ YCQCL 1036_ PGHTG 1041_ QWCEV 1046_ EIDPC 1051_ HSQPC 1056_ FHGGT 1061_ CEATA 1066_ GSPLG 1071_ FICHC 1076_ PKGFE 1081_ GPTCS 1086_ HRAPS 1091_ CGFHH 1096_ CHHGG 1101_ LCLPS 1106_ PKPGF 1111_ PPRCA 1116_ CLSGY 1121_ GGPDC 1126_ LTPPA 1131_ PKGCG 1136_ PPSPC 1141_ LYNGS 1146_ CSETT 1151_ GLGGP 1156_ GFRCS 1161_ CPHSS 1166_ PGPRC 1171_ QKPGA 1176_ KGCEG 1181_ RSGDG 1186_ ACDAG 1191_ CSGPG 1196_ GNWDG 1201_ GDCSL 1206_ GVPDP 1211_ WKGCP 1216_ SHSRC 1221_ WLLFR 1226_ DGQCH 1231_ PQCDS 1236_ EECLF 1241_ DGYDC 1246_ ETPPA 1251_ CTPAY 1256_ DQYCH 1261_ DHFHN 1266_ GHCEK 1271_ GCNTA 1276_ ECGWD 1281_ GGDCR 1286_ PEDGD 1291_ PEWGP 1296_ SLALL 1301_ VVLSP 1306_ PALDQ 1311_ QLFAL 1316_ ARVLS 1321_ LTLRV 1326_ GLWVR 1331_ KDRDG 1336_ RDMVY 1341_ PYPGA 1346_ RAEEK 1351_ LGGTR 1356_ DPTYQ 1361_ ERAAP 1366_ QTQPL 1371_ GKETD 1376_ SLSAG 1381_ FVVVM 1386_ GVDLS 1391_ RCGPD 1396_ HPASR 1401_ CPWDP 1406_ GLLLR 1411_ FLAAM 1416_ AAVGA 1421_ LEPLL 1426_ PGPLL 1431_ AVHPH 1436_ AGTAP 1441_ PANQL 1446_ PWPVL 1451_ CSPVA 1456_ GVILL 1461_ ALGAL 1466_ LVLQL 1471_ IRRRR 1476_ REHGA 1481_ LWLPP 1486_ GFTRR 1491_ PRTQS 1496_ APHRR 1501_ RPPLG 1506_ EDSIG 1511_ LKALK 1516_ PKAEV 1521_ DEDGV 1526_ VMCSG 1531_ PEEGE 1536_ EVGQA 1541_ EETGP 1546_ PSTCQ 1551_ LWSLS 1556_ GGCGA 1561_ LPQAA 1566_ MLTPP 1571_ QESEM 1576_ EAPDL 1581_ DTRGP 1586_ DGVTP 1591_ LMSAV 1596_ CCGEV 1601_ QSGTF 1606_ QGAWL 1611_ GCPEP 1616_ WEPLL 1621_ DGGAC 1626_ PQAHT 1631_ VGTGE 1636_ TPLHL 1641_ AARFS 1646_ RPTAA 1651_ RRLLE 1656_ AGANP 1661_ NQPDR 1666_ AGRTP 1671_ LHAAV 1676_ AADAR 1681_ EVCQL 1686_ LLRSR 1691_ QTAVD 1696_ ARTED 1701_ GTTPL 1706_ MLAAR 1711_ LAVED 1716_ LVEEL 1721_ IAAQA 1726_ DVGAR 1731_ DKWGK 1736_ TALHW 1741_ AAAVN 1746_ NARAA 1751_ RSLLQ 1756_ AGADK 1761_ DAQDN 1766_ REQTP 1771_ LFLAA 1776_ REGAV 1781_ EVAQL 1786_ LLGLG 1791_ AAREL 1796_ RDQAG 1801_ LAPAD 1806_ VAHQR 1811_ NHWDL 1816_ LTLLE 1821_ GAGPP 1826_ EARHK 1831_ ATPGR 1836_ EAGPF 1841_ PRART 1846_ VSVSV 1851_ PPHGG 1856_ GALPR 1861_ CRTLS 1866_ AGAGP 1871_ RGGGA 1876_ CLQAR 1881_ TWSVD 1886_ LAARG 1891_ GGAYS 1896_ HCRSL 1901_ SGVGA 1906_ GGGPT 1911_ PRGRR 1916_ FSAGM 1921_ RGPRP 1926_ NPAIM 1931_ RGRYG 1936_ VAAGR 1941_ GGRVS 1946_ TDDWP 1951_ CDWVA 1956_ LGACG 1961_ SASNI 1966_ PIPPP 1971_ CLTPS 1976_ PERGS 1981_ PQLDC 1986_ GPPAL 1991_ QEMPI 1996_NQGGE
1: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity)