Platelet-activating factor acetylhydrolase 2, cytoplasmic (EC 3.1.1.47) (PAF:lysophospholipid transacetylase) (PAF:sphingosine transacetylase) (Platelet-activating factor acetyltransferase PAFAH2) (EC 2.3.1.149) (Serine-dependent phospholipase A2) (SD-PLA2) (hSD-PLA2)
1_MGVNQ 6_ SVGFP 11_ PVTGP 16_ HLVGC 21_ GDVME 26_ GQNLQ 31_ GSFFR 36_ LFYPC 41_ QKAEE 46_ TMEQP 51_ LWIPR 56_ YEYCT 61_ GLAEY 66_ LQFNK 71_ RCGGL 76_ LFNLA 81_ VGSCR 86_ LPVSW 91_ NGPFK 96_ TKDSG 101_ YPLII 106_ FSHGL 111_ GAFRT 116_ LYSAF 121_ CMELA 126_ SRGFV 131_ VAVPE 136_ HRDRS 141_ AATTY 146_ FCKQA 151_ PEENQ 156_ PTNES 161_ LQEEW 166_ IPFRR 171_ VEEGE 176_ KEFHV 181_ RNPQV 186_ HQRVS 191_ ECLRV 196_ LKILQ 201_ EVTAG 206_ QTVFN 211_ ILPGG 216_ LDLMT 221_ LKGNI 226_ DMSRV 231_ AVMGH 236_ SFGGA 241_ TAILA 246_ LAKET 251_ QFRCA 256_ VALDA 261_ WMFPL 266_ ERDFY 271_ PKARG 276_ PVFFI 281_ NTEKF 286_ QTMES 291_ VNLMK 296_ KICAQ 301_ HEQSR 306_ IITVL 311_ GSVHR 316_ SQTDF 321_ AFVTG 326_ NLIGK 331_ FFSTE 336_ TRGSL 341_ DPYEG 346_ QEVMV 351_ RAMLA 356_ FLQKH 361_ LDLKE 366_ DYNQW 371_ NNLIE 376_ GIGPS 381_ LTPGA 386_PHHLS
1: Catalyzes the hydrolyze of the acetyl group at the sn-2 position of platelet-activating factor (PAF) and its analogs, leading to their inactivation (PubMed:9494101). Hydrolyzes propionyl and butyroyl moieties approximately half as effectively as PAF (By similarity). Also catalyzes transacetylation of the acetyl group from platelet-activating factor (PAF) to lysoplasmalogen and to sphingosine, producing plasmalogen analogs of PAF and N-acetylsphingosine (C2-ceramide) respectively. Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position (By similarity)