Gene name: DDO

Uniprot entry:

Q99489

Protein names:

D-aspartate oxidase (DASOX) (DDO) (EC 1.4.3.1)

Protein sequence:

1_MDTAR 6_ IAVVG 11_ AGVVG 16_ LSTAV 21_ CISKL 26_ VPRCS 31_ VTIIS 36_ DKFTP 41_ DTTSD 46_ VAAGM 51_ LIPHT 56_ YPDTP 61_ IHTQK 66_ QWFRE 71_ TFNHL 76_ FAIAN 81_ SAEAG 86_ DAGVH 91_ LVSGW 96_ QIFQS 101_ TPTEE 106_ VPFWA 111_ DVVLG 116_ FRKMT 121_ EAELK 126_ KFPQY 131_ VFGQA 136_ FTTLK 141_ CECPA 146_ YLPWL 151_ EKRIK 156_ GSGGW 161_ TLTRR 166_ IEDLW 171_ ELHPS 176_ FDIVV 181_ NCSGL 186_ GSRQL 191_ AGDSK 196_ IFPVR 201_ GQVLQ 206_ VQAPW 211_ VEHFI 216_ RDGSG 221_ LTYIY 226_ PGTSH 231_ VTLGG 236_ TRQKG 241_ DWNLS 246_ PDAEN 251_ SREIL 256_ SRCCA 261_ LEPSL 266_ HGACN 271_ IREKV 276_ GLRPY 281_ RPGVR 286_ LQTEL 291_ LARDG 296_ QRLPV 301_ VHHYG 306_ HGSGG 311_ ISVHW 316_ GTALE 321_ AARLV 326_ SECVH 331_ ALRTP 336_IPKSN

Protein annotations

Protein functions:

1: Selectively catalyzes the oxidative deamination of acidic amino acids (PubMed:1991137, PubMed:20603179, PubMed:23391306, PubMed:25747990, PubMed:28393897, PubMed:28560262, PubMed:28629864, PubMed:29292239, PubMed:31914658, PubMed:32553892, PubMed:9163533). Suppresses the level of D-aspartate in the brain, an amino acid that can act as an agonist for glutamate receptors (PubMed:28560262). Protects the organism from the toxicity of D-amino acids (By similarity). May also function in the intestine (By similarity)