Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (GTP-binding and GTPase-activating protein 2) (GGAP2) (Phosphatidylinositol 3-kinase enhancer) (PIKE)
1_MSRGA 6_ GALQR 11_ RTTTY 16_ LISLT 21_ LVKLE 26_ SVPPP 31_ PPSPS 36_ AAAVG 41_ APGAR 46_ GSEPR 51_ DPGSP 56_ RGAEE 61_ PGKKR 66_ HERLF 71_ HRQDA 76_ LWIST 81_ SSAGA 86_ GGAEP 91_ PALSP 96_ APASP 101_ ARPVS 106_ PAPGR 111_ RLSLW 116_ AAPPG 121_ PPLSG 126_ GLSPD 131_ SKPGG 136_ APSSS 141_ RRPLL 146_ SSPSW 151_ GGPEP 156_ EGRTG 161_ GGVPG 166_ SSSPH 171_ PGTGS 176_ RRLKV 181_ APPPP 186_ APKPC 191_ KTVTT 196_ SGAKA 201_ GGGKG 206_ AGSRL 211_ SWPES 216_ EGKPR 221_ VKGSK 226_ SSAGT 231_ GASVS 236_ AAATA 241_ AAAGG 246_ GGSTA 251_ STSGG 256_ VGAGA 261_ GARGK 266_ LSPRK 271_ GKSKT 276_ LDNSD 281_ LHPGP 286_ PAGSP 291_ PPLTL 296_ PPTPS 301_ PATAV 306_ TAASA 311_ QPPGP 316_ APPIT 321_ LEPPA 326_ PGLKR 331_ GREGG 336_ RASTR 341_ DRKML 346_ KFISG 351_ IFTKS 356_ TGGPP 361_ GSGPL 366_ PGPPS 371_ LSSGS 376_ GSREL 381_ LGAEL 386_ RASPK 391_ AVINS 396_ QEWTL 401_ SRSIP 406_ ELRLG 411_ VLGDA 416_ RSGKS 421_ SLIHR 426_ FLTGS 431_ YQVLE 436_ KTESE 441_ QYKKE 446_ MLVDG 451_ QTHLV 456_ LIREE 461_ AGAPD 466_ AKFSG 471_ WADAV 476_ IFVFS 481_ LEDEN 486_ SFQAV 491_ SRLHG 496_ QLSSL 501_ RGEGR 506_ GGLAL 511_ ALVGT 516_ QDRIS 521_ ASSPR 526_ VVGDA 531_ RARAL 536_ CADMK 541_ RCSYY 546_ ETCAT 551_ YGLNV 556_ DRVFQ 561_ EVAQK 566_ VVTLR 571_ KQQQL 576_ LAACK 581_ SLPSS 586_ PSHSA 591_ ASTPV 596_ AGQAS 601_ NGGHT 606_ SDYSS 611_ SLPSS 616_ PNVGH 621_ RELRA 626_ EAAAV 631_ AGLST 636_ PGSLH 641_ RAAKR 646_ RTSLF 651_ ANRRG 656_ SDSEK 661_ RSLDS 666_ RGETT 671_ GSGRA 676_ IPIKQ 681_ SFLLK 686_ RSGNS 691_ LNKEW 696_ KKKYV 701_ TLSSN 706_ GFLLY 711_ HPSIN 716_ DYIHS 721_ THGKE 726_ MDLLR 731_ TTVKV 736_ PGKRP 741_ PRAIS 746_ AFGPS 751_ ASING 756_ LVKDM 761_ STVQM 766_ GEGLE 771_ ATTPM 776_ PSPSP 781_ SPSSL 786_ QPPPD 791_ QTSKH 796_ LLKPD 801_ RNLAR 806_ ALSTD 811_ CTPSG 816_ DLSPL 821_ SREPP 826_ PSPMV 831_ KKQRR 836_ KKLTT 841_ PSKTE 846_ GSAGQ 851_ AEAKR 856_ KMWKL 861_ KSFGS 866_ LRNIY 871_ KAEEN 876_ FEFLI 881_ VSSTG 886_ QTWHF 891_ EAASF 896_ EERDA 901_ WVQAI 906_ ESQIL 911_ ASLQC 916_ CESSK 921_ VKLRT 926_ DSQSE 931_ AVAIQ 936_ AIRNA 941_ KGNSI 946_ CVDCG 951_ APNPT 956_ WASLN 961_ LGALI 966_ CIECS 971_ GIHRN 976_ LGTHL 981_ SRVRS 986_ LDLDD 991_ WPREL 996_ TLVLT 1001_ AIGND 1006_ TANRV 1011_ WESDT 1016_ RGRAK 1021_ PSRDS 1026_ SREER 1031_ ESWIR 1036_ AKYEQ 1041_ LLFLA 1046_ PLSTS 1051_ EEPLG 1056_ RQLWA 1061_ AVQAQ 1066_ DVATV 1071_ LLLLA 1076_ HARHG 1081_ PLDTS 1086_ VEDPQ 1091_ LRSPL 1096_ HLAAE 1101_ LAHVV 1106_ ITQLL 1111_ LWYGA 1116_ DVAAR 1121_ DAQGR 1126_ TALFY 1131_ ARQAG 1136_ SQLCA 1141_ DILLQ 1146_ HGCPG 1151_ EGGSA 1156_ ATTPS 1161_ AATTP 1166_ SITAT 1171_ PSPRR 1176_ RSSAA 1181_ SVGRA 1186_DAPVA
1: GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion