Eyes absent homolog 1 (EC 3.1.3.16) (EC 3.1.3.48)
1_MEMQD 6_ LTSPH 11_ SRLSG 16_ SSESP 21_ SGPKL 26_ GNSHI 31_ NSNSM 36_ TPNGT 41_ EVKTE 46_ PMSSS 51_ ETAST 56_ TADGS 61_ LNNFS 66_ GSAIG 71_ SSSFS 76_ PRPTH 81_ QFSPP 86_ QIYPS 91_ NRPYP 96_ HILPT 101_ PSSQT 106_ MAAYG 111_ QTQFT 116_ TGMQQ 121_ ATAYA 126_ TYPQP 131_ GQPYG 136_ ISSYG 141_ ALWAG 146_ IKTEG 151_ GLSQS 156_ QSPGQ 161_ TGFLS 166_ YGTSF 171_ STPQP 176_ GQAPY 181_ SYQMQ 186_ GSSFT 191_ TSSGI 196_ YTGNN 201_ SLTNS 206_ SGFNS 211_ SQQDY 216_ PSYPS 221_ FGQGQ 226_ YAQYY 231_ NSSPY 236_ PAHYM 241_ TSSNT 246_ SPTTP 251_ STNAT 256_ YQLQE 261_ PPSGI 266_ TSQAV 271_ TDPTA 276_ EYSTI 281_ HSPST 286_ PIKDS 291_ DSDRL 296_ RRGSD 301_ GKSRG 306_ RGRRN 311_ NNPSP 316_ PPDSD 321_ LERVF 326_ IWDLD 331_ ETIIV 336_ FHSLL 341_ TGSYA 346_ NRYGR 351_ DPPTS 356_ VSLGL 361_ RMEEM 366_ IFNLA 371_ DTHLF 376_ FNDLE 381_ ECDQV 386_ HIDDV 391_ SSDDN 396_ GQDLS 401_ TYNFG 406_ TDGFP 411_ AAATS 416_ ANLCL 421_ ATGVR 426_ GGVDW 431_ MRKLA 436_ FRYRR 441_ VKEIY 446_ NTYKN 451_ NVGGL 456_ LGPAK 461_ REAWL 466_ QLRAE 471_ IEALT 476_ DSWLT 481_ LALKA 486_ LSLIH 491_ SRTNC 496_ VNILV 501_ TTTQL 506_ IPALA 511_ KVLLY 516_ GLGIV 521_ FPIEN 526_ IYSAT 531_ KIGKE 536_ SCFER 541_ IIQRF 546_ GRKVV 551_ YVVIG 556_ DGVEE 561_ EQGAK 566_ KHAMP 571_ FWRIS 576_ SHSDL 581_ MALHH 586_ALELE
1: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (By similarity). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19234442). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis (By similarity). Also has phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro) (By similarity). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears (By similarity). Together with SIX1, it plays an important role in hypaxial muscle development; in this it is functionally redundant with EYA2 (By similarity)