Eyes absent homolog 3 (EC 3.1.3.48)
1_MEEEQ 6_ DLPEQ 11_ PVKKA 16_ KMQES 21_ GEQTI 26_ SQVSN 31_ PDVSD 36_ QKPET 41_ SSLAS 46_ NLPMS 51_ EEIMT 56_ CTDYI 61_ PRSSN 66_ DYTSQ 71_ MYSAK 76_ PYAHI 81_ LSVPV 86_ SETAY 91_ PGQTQ 96_ YQTLQ 101_ QTQPY 106_ AVYPQ 111_ ATQTY 116_ GLPPF 121_ GALWP 126_ GMKPE 131_ SGLIQ 136_ TPSPS 141_ QHSVL 146_ TCTTG 151_ LTTSQ 156_ PSPAH 161_ YSYPI 166_ QASST 171_ NASLI 176_ STSST 181_ IANIP 186_ AAAVA 191_ SISNQ 196_ DYPTY 201_ TILGQ 206_ NQYQA 211_ CYPSS 216_ SFGVT 221_ GQTNS 226_ DAEST 231_ TLAAT 236_ TYQSE 241_ KPSVM 246_ APAPA 251_ AQRLS 256_ SGDPS 261_ TSPSL 266_ SQTTP 271_ SKDTD 276_ DQSRK 281_ NMTSK 286_ NRGKR 291_ KADAT 296_ SSQDS 301_ ELERV 306_ FLWDL 311_ DETII 316_ IFHSL 321_ LTGSY 326_ AQKYG 331_ KDPTV 336_ VIGSG 341_ LTMEE 346_ MIFEV 351_ ADTHL 356_ FFNDL 361_ EECDQ 366_ VHVED 371_ VASDD 376_ NGQDL 381_ SNYSF 386_ STDGF 391_ SGSGG 396_ SGSHG 401_ SSVGV 406_ QGGVD 411_ WMRKL 416_ AFRYR 421_ KVREI 426_ YDKHK 431_ SNVGG 436_ LLSPQ 441_ RKEAL 446_ QRLRA 451_ EIEVL 456_ TDSWL 461_ GTALK 466_ SLLLI 471_ QSRKN 476_ CVNVL 481_ ITTTQ 486_ LVPAL 491_ AKVLL 496_ YGLGE 501_ IFPIE 506_ NIYSA 511_ TKIGK 516_ ESCFE 521_ RIVSR 526_ FGKKV 531_ TYVVI 536_ GDGRD 541_ EEIAA 546_ KQHNM 551_ PFWRI 556_ TNHGD 561_ LVSLH 566_QALEL
1: Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye