Flavin-containing monooxygenase 2 (EC 1.14.13.-) (Dimethylaniline oxidase 2) (FMO 1B1) (Pulmonary flavin-containing monooxygenase 2) (FMO 2)
1_MAKKV 6_ AVIGA 11_ GVSGL 16_ ISLKC 21_ CVDEG 26_ LEPTC 31_ FERTE 36_ DIGGV 41_ WRFKE 46_ NVEDG 51_ RASIY 56_ QSVVT 61_ NTSKE 66_ MSCFS 71_ DFPMP 76_ EDFPN 81_ FLHNS 86_ KLLEY 91_ FRIFA 96_ KKFDL 101_ LKYIQ 106_ FQTTV 111_ LSVRK 116_ CPDFS 121_ SSGQW 126_ KVVTQ 131_ SNGKE 136_ QSAVF 141_ DAVMV 146_ CSGHH 151_ ILPHI 156_ PLKSF 161_ PGMER 166_ FKGQY 171_ FHSRQ 176_ YKHPD 181_ GFEGK 186_ RILVI 191_ GMGNS 196_ GSDIA 201_ VELSK 206_ NAAQV 211_ FISTR 216_ HGTWV 221_ MSRIS 226_ EDGYP 231_ WDSVF 236_ HTRFR 241_ SMLRN 246_ VLPRT 251_ AVKWM 256_ IEQQM 261_ NRWFN 266_ HENYG 271_ LEPQN 276_ KYIMK 281_ EPVLN 286_ DDVPS 291_ RLLCG 296_ AIKVK 301_ STVKE 306_ LTETS 311_ AIFED 316_ GTVEE 321_ NIDVI 326_ IFATG 331_ YSFSF 336_ PFLED 341_ SLVKV 346_ ENNMV 351_ SLYKY 356_ IFPAH 361_ LDKST 366_ LACIG 371_ LIQPL 376_ GSIFP 381_ TAELQ 386_ ARWVT 391_ RVFKG 396_ LCSLP 401_ SERTM 406_ MMDII 411_ KRNEK 416_ RIDLF 421_ GESQS 426_ QTLQT 431_ NYVDY 436_ LDELA 441_ LEIGA 446_ KPDFC 451_ SLLFK 456_ DPKLA 461_ VRLYF 466_ GPCNS 471_ YQYRL 476_ VGPGQ 481_ WEGAR 486_ NAIFT 491_ QKQRI 496_ LKPLK 501_ TRALK 506_ DSSNF 511_ SVSFL 516_ LKILG 521_ LLAVV 526_VAFFC
1: Catalyzes the oxidative metabolism of numerous xenobiotics, including mainly therapeutic drugs and insecticides that contain a soft nucleophile, most commonly nitrogen and sulfur and participates to their bioactivation (PubMed:15144220, PubMed:15294458, PubMed:18930751, PubMed:18948378, PubMed:9804831). Specifically catalyzes S-oxygenation of sulfur derived compounds such as thioureas-derived compounds, thioetherorganophosphates to their sulfenic acid (PubMed:15144220, PubMed:9804831). In vitro, catalyzes S-oxygenation of the second-line antitubercular drugs thiacetazone (TAZ) and ethionamide (ETA), forming a sulfinic acid and a carbodiimide via a postulated sulfenic acid intermediate (PubMed:18930751, PubMed:18948378). Also catalyzes S-oxygenation of the thioether-containing organophosphate insecticides, phorate and disulfoton (PubMed:15294458)