Sialidase-1 (EC 3.2.1.18) (Acetylneuraminyl hydrolase) (G9 sialidase) (Lysosomal sialidase) (N-acetyl-alpha-neuraminidase 1)
1_MTGER 6_ PSTAL 11_ PDRRW 16_ GPRIL 21_ GFWGG 26_ CRVWV 31_ FAAIF 36_ LLLSL 41_ AASWS 46_ KAEND 51_ FGLVQ 56_ PLVTM 61_ EQLLW 66_ VSGRQ 71_ IGSVD 76_ TFRIP 81_ LITAT 86_ PRGTL 91_ LAFAE 96_ ARKMS 101_ SSDEG 106_ AKFIA 111_ LRRSM 116_ DQGST 121_ WSPTA 126_ FIVND 131_ GDVPD 136_ GLNLG 141_ AVVSD 146_ VETGV 151_ VFLFY 156_ SLCAH 161_ KAGCQ 166_ VASTM 171_ LVWSK 176_ DDGVS 181_ WSTPR 186_ NLSLD 191_ IGTEV 196_ FAPGP 201_ GSGIQ 206_ KQREP 211_ RKGRL 216_ IVCGH 221_ GTLER 226_ DGVFC 231_ LLSDD 236_ HGASW 241_ RYGSG 246_ VSGIP 251_ YGQPK 256_ QENDF 261_ NPDEC 266_ QPYEL 271_ PDGSV 276_ VINAR 281_ NQNNY 286_ HCHCR 291_ IVLRS 296_ YDACD 301_ TLRPR 306_ DVTFD 311_ PELVD 316_ PVVAA 321_ GAVVT 326_ SSGIV 331_ FFSNP 336_ AHPEF 341_ RVNLT 346_ LRWSF 351_ SNGTS 356_ WRKET 361_ VQLWP 366_ GPSGY 371_ SSLAT 376_ LEGSM 381_ DGEEQ 386_ APQLY 391_ VLYEK 396_ GRNHY 401_ TESIS 406_VAKIS
1: Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage