Sortilin (100 kDa NT receptor) (Glycoprotein 95) (Gp95) (Neurotensin receptor 3) (NT3) (NTR3)
1_MERPW 6_ GAADG 11_ LSRWP 16_ HGLGL 21_ LLLLQ 26_ LLPPS 31_ TLSQD 36_ RLDAP 41_ PPPAA 46_ PLPRW 51_ SGPIG 56_ VSWGL 61_ RAAAA 66_ GGAFP 71_ RGGRW 76_ RRSAP 81_ GEDEE 86_ CGRVR 91_ DFVAK 96_ LANNT 101_ HQHVF 106_ DDLRG 111_ SVSLS 116_ WVGDS 121_ TGVIL 126_ VLTTF 131_ HVPLV 136_ IMTFG 141_ QSKLY 146_ RSEDY 151_ GKNFK 156_ DITDL 161_ INNTF 166_ IRTEF 171_ GMAIG 176_ PENSG 181_ KVVLT 186_ AEVSG 191_ GSRGG 196_ RIFRS 201_ SDFAK 206_ NFVQT 211_ DLPFH 216_ PLTQM 221_ MYSPQ 226_ NSDYL 231_ LALST 236_ ENGLW 241_ VSKNF 246_ GGKWE 251_ EIHKA 256_ VCLAK 261_ WGSDN 266_ TIFFT 271_ TYANG 276_ SCKAD 281_ LGALE 286_ LWRTS 291_ DLGKS 296_ FKTIG 301_ VKIYS 306_ FGLGG 311_ RFLFA 316_ SVMAD 321_ KDTTR 326_ RIHVS 331_ TDQGD 336_ TWSMA 341_ QLPSV 346_ GQEQF 351_ YSILA 356_ ANDDM 361_ VFMHV 366_ DEPGD 371_ TGFGT 376_ IFTSD 381_ DRGIV 386_ YSKSL 391_ DRHLY 396_ TTTGG 401_ ETDFT 406_ NVTSL 411_ RGVYI 416_ TSVLS 421_ EDNSI 426_ QTMIT 431_ FDQGG 436_ RWTHL 441_ RKPEN 446_ SECDA 451_ TAKNK 456_ NECSL 461_ HIHAS 466_ YSISQ 471_ KLNVP 476_ MAPLS 481_ EPNAV 486_ GIVIA 491_ HGSVG 496_ DAISV 501_ MVPDV 506_ YISDD 511_ GGYSW 516_ TKMLE 521_ GPHYY 526_ TILDS 531_ GGIIV 536_ AIEHS 541_ SRPIN 546_ VIKFS 551_ TDEGQ 556_ CWQTY 561_ TFTRD 566_ PIYFT 571_ GLASE 576_ PGARS 581_ MNISI 586_ WGFTE 591_ SFLTS 596_ QWVSY 601_ TIDFK 606_ DILER 611_ NCEEK 616_ DYTIW 621_ LAHST 626_ DPEDY 631_ EDGCI 636_ LGYKE 641_ QFLRL 646_ RKSSV 651_ CQNGR 656_ DYVVT 661_ KQPSI 666_ CLCSL 671_ EDFLC 676_ DFGYY 681_ RPEND 686_ SKCVE 691_ QPELK 696_ GHDLE 701_ FCLYG 706_ REEHL 711_ TTNGY 716_ RKIPG 721_ DKCQG 726_ GVNPV 731_ REVKD 736_ LKKKC 741_ TSNFL 746_ SPEKQ 751_ NSKSN 756_ SVPII 761_ LAIVG 766_ LMLVT 771_ VVAGV 776_ LIVKK 781_ YVCGG 786_ RFLVH 791_ RYSVL 796_ QQHAE 801_ ANGVD 806_ GVDAL 811_ DTASH 816_ TNKSG 821_ YHDDS 826_DEDLL
1: Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:16787399). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi