G-protein coupled estrogen receptor 1 (Chemoattractant receptor-like 2) (Flow-induced endothelial G-protein coupled receptor 1) (FEG-1) (G protein-coupled estrogen receptor 1) (G-protein coupled receptor 30) (GPCR-Br) (IL8-related receptor DRY12) (Lymphocyte-derived G-protein coupled receptor) (LYGPR) (Membrane estrogen receptor) (mER)
1_MDVTS 6_ QARGV 11_ GLEMY 16_ PGTAQ 21_ PAAPN 26_ TTSPE 31_ LNLSH 36_ PLLGT 41_ ALANG 46_ TGELS 51_ EHQQY 56_ VIGLF 61_ LSCLY 66_ TIFLF 71_ PIGFV 76_ GNILI 81_ LVVNI 86_ SFREK 91_ MTIPD 96_ LYFIN 101_ LAVAD 106_ LILVA 111_ DSLIE 116_ VFNLH 121_ ERYYD 126_ IAVLC 131_ TFMSL 136_ FLQVN 141_ MYSSV 146_ FFLTW 151_ MSFDR 156_ YIALA 161_ RAMRC 166_ SLFRT 171_ KHHAR 176_ LSCGL 181_ IWMAS 186_ VSATL 191_ VPFTA 196_ VHLQH 201_ TDEAC 206_ FCFAD 211_ VREVQ 216_ WLEVT 221_ LGFIV 226_ PFAII 231_ GLCYS 236_ LIVRV 241_ LVRAH 246_ RHRGL 251_ RPRRQ 256_ KALRM 261_ ILAVV 266_ LVFFV 271_ CWLPE 276_ NVFIS 281_ VHLLQ 286_ RTQPG 291_ AAPCK 296_ QSFRH 301_ AHPLT 306_ GHIVN 311_ LAAFS 316_ NSCLN 321_ PLIYS 326_ FLGET 331_ FRDKL 336_ RLYIE 341_ QKTNL 346_ PALNR 351_ FCHAA 356_ LKAVI 361_ PDSTE 366_QSDVR
1: G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. Also functions as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway. Involved in cancer progression regulation. Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR/ERK transduction pathway. Associated with EGFR, may act as a transcription factor activating growth regulatory genes (c-fos, cyclin D1). Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells