DnaJ homolog subfamily C member 2 (M-phase phosphoprotein 11) (Zuotin-related factor 1) [Cleaved into: DnaJ homolog subfamily C member 2, N-terminally processed]
1_MLLLP 6_ SAADG 11_ RGTAI 16_ THALT 21_ SASTL 26_ CQVEP 31_ VGRWF 36_ EAFVK 41_ RRNRN 46_ ASASF 51_ QELED 56_ KKELS 61_ EESED 66_ EELQL 71_ EEFPM 76_ LKTLD 81_ PKDWK 86_ NQDHY 91_ AVLGL 96_ GHVRY 101_ KATQR 106_ QIKAA 111_ HKAMV 116_ LKHHP 121_ DKRKA 126_ AGEPI 131_ KEGDN 136_ DYFTC 141_ ITKAY 146_ EMLSD 151_ PVKRR 156_ AFNSV 161_ DPTFD 166_ NSVPS 171_ KSEAK 176_ DNFFE 181_ VFTPV 186_ FERNS 191_ RWSNK 196_ KNVPK 201_ LGDMN 206_ SSFED 211_ VDIFY 216_ SFWYN 221_ FDSWR 226_ EFSYL 231_ DEEEK 236_ EKAEC 241_ RDERR 246_ WIEKQ 251_ NRATR 256_ AQRKK 261_ EEMNR 266_ IRTLV 271_ DNAYS 276_ CDPRI 281_ KKFKE 286_ EEKAK 291_ KEAEK 296_ KAKAE 301_ AKRKE 306_ QEAKE 311_ KQRQA 316_ ELEAA 321_ RLAKE 326_ KEEEE 331_ VRQQA 336_ LLAKK 341_ EKDIQ 346_ KKAIK 351_ KERQK 356_ LRNSC 361_ KTWNH 366_ FSDNE 371_ AERVK 376_ MMEEV 381_ EKLCD 386_ RLELA 391_ SLQCL 396_ NETLT 401_ SCTKE 406_ VGKAA 411_ LEKQI 416_ EEINE 421_ QIRKE 426_ KEEAE 431_ ARMRQ 436_ ASKNT 441_ EKSTG 446_ GGGNG 451_ SKNWS 456_ EDDLQ 461_ LLIKA 466_ VNLFP 471_ AGTNS 476_ RWEVI 481_ ANYMN 486_ IHSSS 491_ GVKRT 496_ AKDVI 501_ GKAKS 506_ LQKLD 511_ PHQKD 516_ DINKK 521_ AFDKF 526_ KKEHG 531_ VVPQA 536_ DNATP 541_ SERFE 546_ GPYTD 551_ FTPWT 556_ TEEQK 561_ LLEQA 566_ LKTYP 571_ VNTPE 576_ RWEKI 581_ AEAVP 586_ GRTKK 591_ DCMKR 596_ YKELV 601_ EMVKA 606_ KKAAQ 611_ EQVLN 616_ASRAK
1: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation