Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK)
1_MAVME 6_ MACPG 11_ APGSA 16_ VGQQK 21_ ELPKA 26_ KEKTP 31_ PLGKK 36_ QSSVY 41_ KLEAV 46_ EKSPV 51_ FCGKW 56_ EILND 61_ VITKG 66_ TAKEG 71_ SEAGP 76_ AAISI 81_ IAQAE 86_ CENSQ 91_ EFSPT 96_ FSERI 101_ FIAGS 106_ KQYSQ 111_ SESLD 116_ QIPNN 121_ VAHAT 126_ EGKMA 131_ RVCWK 136_ GKRRS 141_ KARKK 146_ RKKKS 151_ SKSLA 156_ HAGVA 161_ LAKPL 166_ PRTPE 171_ QESCT 176_ IPVQE 181_ DESPL 186_ GAPYV 191_ RNTPQ 196_ FTKPL 201_ KEPGL 206_ GQLCF 211_ KQLGE 216_ GLRPA 221_ LPRSE 226_ LHKLI 231_ SPLQC 236_ LNHVW 241_ KLHHP 246_ QDGGP 251_ LPLPT 256_ HPFPY 261_ SRLPH 266_ PFPFH 271_ PLQPW 276_ KPHPL 281_ ESFLG 286_ KLACV 291_ DSQKP 296_ LPDPH 301_ LSKLA 306_ CVDSP 311_ KPLPG 316_ PHLEP 321_ SCLSR 326_ GAHEK 331_ FSVEE 336_ YLVHA 341_ LQGSV 346_ SSGQA 351_ HSLTS 356_ LAKTW 361_ AARGS 366_ RSREP 371_ SPKTE 376_ DNEGV 381_ LLTEK 386_ LKPVD 391_ YEYRE 396_ EVHWA 401_ THQLR 406_ LGRGS 411_ FGEVH 416_ RMEDK 421_ QTGFQ 426_ CAVKK 431_ VRLEV 436_ FRAEE 441_ LMACA 446_ GLTSP 451_ RIVPL 456_ YGAVR 461_ EGPWV 466_ NIFME 471_ LLEGG 476_ SLGQL 481_ VKEQG 486_ CLPED 491_ RALYY 496_ LGQAL 501_ EGLEY 506_ LHSRR 511_ ILHGD 516_ VKADN 521_ VLLSS 526_ DGSHA 531_ ALCDF 536_ GHAVC 541_ LQPDG 546_ LGKSL 551_ LTGDY 556_ IPGTE 561_ THMAP 566_ EVVLG 571_ RSCDA 576_ KVDVW 581_ SSCCM 586_ MLHML 591_ NGCHP 596_ WTQFF 601_ RGPLC 606_ LKIAS 611_ EPPPV 616_ REIPP 621_ SCAPL 626_ TAQAI 631_ QEGLR 636_ KEPIH 641_ RVSAA 646_ ELGGK 651_ VNRAL 656_ QQVGG 661_ LKSPW 666_ RGEYK 671_ EPRHP 676_ PPNQA 681_ NYHQT 686_ LHAQP 691_ RELSP 696_ RAPGP 701_ RPAEE 706_ TTGRA 711_ PKLQP 716_ PLPPE 721_ PPEPN 726_ KSPPL 731_ TLSKE 736_ ESGMW 741_ EPLPL 746_ SSLEP 751_ APARN 756_ PSSPE 761_ RKATV 766_ PEQEL 771_ QQLEI 776_ ELFLN 781_ SLSQP 786_ FSLEE 791_ QEQIL 796_ SCLSI 801_ DSLSL 806_ SDDSE 811_ KNPSK 816_ ASQSS 821_ RDTLS 826_ SGVHS 831_ WSSQA 836_ EARSS 841_ SWNMV 846_ LARGR 851_ PTDTP 856_ SYFNG 861_ VKVQI 866_ QSLNG 871_ EHLHI 876_ REFHR 881_ VKVGD 886_ IATGI 891_ SSQIP 896_ AAAFS 901_ LVTKD 906_ GQPVR 911_ YDMEV 916_ PDSGI 921_ DLQCT 926_ LAPDG 931_ SFAWS 936_ WRVKH 941_GQLEN
1: Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Phosphorylates CHUK/IKKA, thereby promoting proteolytic processing of NFKB2/P100, which leads to NF-kappa-B activation via the non-canonical pathway (PubMed:25406581, PubMed:29230214). Has an essential role in the non-canonical NF-kappa-B signaling that regulates genes encoding molecules involved in B-cell survival, lymphoid organogenesis, and immune response (PubMed:25406581). Could act in a receptor-selective manner