P2X purinoceptor 4 (P2X4) (ATP receptor) (Purinergic receptor)
1_MAGCC 6_ AALAA 11_ FLFEY 16_ DTPRI 21_ VLIRS 26_ RKVGL 31_ MNRAV 36_ QLLIL 41_ AYVIG 46_ WVFVW 51_ EKGYQ 56_ ETDSV 61_ VSSVT 66_ TKVKG 71_ VAVTN 76_ TSKLG 81_ FRIWD 86_ VADYV 91_ IPAQE 96_ ENSLF 101_ VMTNV 106_ ILTMN 111_ QTQGL 116_ CPEIP 121_ DATTV 126_ CKSDA 131_ SCTAG 136_ SAGTH 141_ SNGVS 146_ TGRCV 151_ AFNGS 156_ VKTCE 161_ VAAWC 166_ PVEDD 171_ THVPQ 176_ PAFLK 181_ AAENF 186_ TLLVK 191_ NNIWY 196_ PKFNF 201_ SKRNI 206_ LPNIT 211_ TTYLK 216_ SCIYD 221_ AKTDP 226_ FCPIF 231_ RLGKI 236_ VENAG 241_ HSFQD 246_ MAVEG 251_ GIMGI 256_ QVNWD 261_ CNLDR 266_ AASLC 271_ LPRYS 276_ FRRLD 281_ TRDVE 286_ HNVSP 291_ GYNFR 296_ FAKYY 301_ RDLAG 306_ NEQRT 311_ LIKAY 316_ GIRFD 321_ IIVFG 326_ KAGKF 331_ DIIPT 336_ MINIG 341_ SGLAL 346_ LGMAT 351_ VLCDI 356_ IVLYC 361_ MKKRL 366_ YYREK 371_ KYKYV 376_ EDYEQ 381_GLASE
1: ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (PubMed:9016352). CTP, but not GTP or UTP, functions as a weak affinity agonist for P2RX4 (By similarity). Activated by extracellularly released ATP, it plays multiple role in immunity and central nervous system physiology (PubMed:35165166). Plays a key role in initial steps of T-cell activation and Ca(2+) microdomain formation (By similarity). Also participates in basal T-cell activity without TCR/CD3 stimulation (By similarity). Promotes the differentiation and activation of Th17 cells via expression of retinoic acid-related orphan receptor C/RORC (PubMed:35165166). Upon activation, drives microglia motility via the PI3K/Akt pathway (By similarity). Could also function as an ATP-gated cation channel of lysosomal membranes (By similarity)