P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor)
1_MPACC 6_ SCSDV 11_ FQYET 16_ NKVTR 21_ IQSMN 26_ YGTIK 31_ WFFHV 36_ IIFSY 41_ VCFAL 46_ VSDKL 51_ YQRKE 56_ PVISS 61_ VHTKV 66_ KGIAE 71_ VKEEI 76_ VENGV 81_ KKLVH 86_ SVFDT 91_ ADYTF 96_ PLQGN 101_ SFFVM 106_ TNFLK 111_ TEGQE 116_ QRLCP 121_ EYPTR 126_ RTLCS 131_ SDRGC 136_ KKGWM 141_ DPQSK 146_ GIQTG 151_ RCVVY 156_ EGNQK 161_ TCEVS 166_ AWCPI 171_ EAVEE 176_ APRPA 181_ LLNSA 186_ ENFTV 191_ LIKNN 196_ IDFPG 201_ HNYTT 206_ RNILP 211_ GLNIT 216_ CTFHK 221_ TQNPQ 226_ CPIFR 231_ LGDIF 236_ RETGD 241_ NFSDV 246_ AIQGG 251_ IMGIE 256_ IYWDC 261_ NLDRW 266_ FHHCR 271_ PKYSF 276_ RRLDD 281_ KTTNV 286_ SLYPG 291_ YNFRY 296_ AKYYK 301_ ENNVE 306_ KRTLI 311_ KVFGI 316_ RFDIL 321_ VFGTG 326_ GKFDI 331_ IQLVV 336_ YIGST 341_ LSYFG 346_ LAAVF 351_ IDFLI 356_ DTYSS 361_ NCCRS 366_ HIYPW 371_ CKCCQ 376_ PCVVN 381_ EYYYR 386_ KKCES 391_ IVEPK 396_ PTLKY 401_ VSFVD 406_ ESHIR 411_ MVNQQ 416_ LLGRS 421_ LQDVK 426_ GQEVP 431_ RPAMD 436_ FTDLS 441_ RLPLA 446_ LHDTP 451_ PIPGQ 456_ PEEIQ 461_ LLRKE 466_ ATPRS 471_ RDSPV 476_ WCQCG 481_ SCLPS 486_ QLPES 491_ HRCLE 496_ ELCCR 501_ KKPGA 506_ CITTS 511_ ELFRK 516_ LVLSR 521_ HVLQF 526_ LLLYQ 531_ EPLLA 536_ LDVDS 541_ TNSRL 546_ RHCAY 551_ RCYAT 556_ WRFGS 561_ QDMAD 566_ FAILP 571_ SCCRW 576_ RIRKE 581_ FPKSE 586_GQYSG
1: ATP-gated nonselective transmembrane cation channel that requires high millimolar concentrations of ATP for activation (PubMed:17483156, PubMed:25281740, PubMed:9038151). Upon ATP binding, it rapidly opens to allow the influx of small cations Na(+) and Ca(2+), and the K(+) efflux (PubMed:17483156, PubMed:20453110, PubMed:28235784, PubMed:39262850). Also has the ability to form a large pore in the cell membrane, allowing the passage of large cationic molecules (PubMed:17483156). In microglia, may mediate NADPH transport across the plasma membrane (PubMed:39142135). In immune cells, P2RX7 acts as a molecular sensor in pathological inflammatory states by detecting and responding to high local concentrations of extracellar ATP. In microglial cells, P2RX7 activation leads to the release of pro-inflammatory cytokines, such as IL-1beta and IL-18, through the activation of the NLRP3 inflammasome and caspase-1 (PubMed:26877061). Cooperates with KCNK6 to activate NLRP3 inflammasome (By similarity). Activates death pathways leading to apoptosis and autophagy (PubMed:21821797, PubMed:23303206, PubMed:28326637). Activates death pathways leading to pyroptosis (By similarity)
2: Shows ion channel activity but no macropore function
3: Non-functional channel
4: Non-functional channel