TSC22 domain family protein 3 (DSIP-immunoreactive peptide) (Protein DIP) (hDIP) (Delta sleep-inducing peptide immunoreactor) (Glucocorticoid-induced leucine zipper protein) (GILZ) (TSC-22-like protein) (TSC-22-related protein) (TSC-22R)
1_MNTEM 6_ YQTPM 11_ EVAVY 16_ QLHNF 21_ SISFF 26_ SSLLG 31_ GDVVS 36_ VKLDN 41_ SASGA 46_ SVVAI 51_ DNKIE 56_ QAMDL 61_ VKNHL 66_ MYAVR 71_ EEVEI 76_ LKEQI 81_ RELVE 86_ KNSQL 91_ ERENT 96_ LLKTL 101_ ASPEQ 106_ LEKFQ 111_ SCLSP 116_ EEPAP 121_ ESPQV 126_PEAPG
1: Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11 (PubMed:15031210). In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10 (PubMed:12393603). In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation and thereby NFKB1 DNA-binding activities (PubMed:11468175). In vitro, suppresses AP-1 transcription factor complex DNA-binding activities (By similarity)
2: Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG