Transcriptional enhancer factor TEF-5 (DTEF-1) (TEA domain family member 3) (TEAD-3)
1_MASNS 6_ WNASS 11_ SPGEA 16_ REDGP 21_ EGLDK 26_ GLDND 31_ AEGVW 36_ SPDIE 41_ QSFQE 46_ ALAIY 51_ PPCGR 56_ RKIIL 61_ SDEGK 66_ MYGRN 71_ ELIAR 76_ YIKLR 81_ TGKTR 86_ TRKQV 91_ SSHIQ 96_ VLARK 101_ KVREY 106_ QVGIK 111_ AMNLD 116_ QVSKD 121_ KALQS 126_ MASMS 131_ SAQIV 136_ SASVL 141_ QNKFS 146_ PPSPL 151_ PQAVF 156_ STSSR 161_ FWSSP 166_ PLLGQ 171_ QPGPS 176_ QDIKP 181_ FAQPA 186_ YPIQP 191_ PLPPT 196_ LSSYE 201_ PLAPL 206_ PSAAA 211_ SVPVW 216_ QDRTI 221_ ASSRL 226_ RLLEY 231_ SAFME 236_ VQRDP 241_ DTYSK 246_ HLFVH 251_ IGQTN 256_ PAFSD 261_ PPLEA 266_ VDVRQ 271_ IYDKF 276_ PEKKG 281_ GLKEL 286_ YEKGP 291_ PNAFF 296_ LVKFW 301_ ADLNS 306_ TIQEG 311_ PGAFY 316_ GVSSQ 321_ YSSAD 326_ SMTIS 331_ VSTKV 336_ CSFGK 341_ QVVEK 346_ VETEY 351_ ARLEN 356_ GRFVY 361_ RIHRS 366_ PMCEY 371_ MINFI 376_ HKLKH 381_ LPEKY 386_ MMNSV 391_ LENFT 396_ ILQVV 401_ TSRDS 406_ QETLL 411_ VIAFV 416_ FEVST 421_ SEHGA 426_QHHVY
1: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer