Necdin
1_MSEQS 6_ KDLSD 11_ PNFAA 16_ EAPNS 21_ EVHSS 26_ PGVSE 31_ GVPPS 36_ ATLAE 41_ PQSPP 46_ LGPTA 51_ APQAA 56_ PPPQA 61_ PNDEG 66_ DPKAL 71_ QQAAE 76_ EGRAH 81_ QAPSA 86_ AQPGP 91_ APPAP 96_ AQLVQ 101_ KAHEL 106_ MWYVL 111_ VKDQK 116_ KMIIW 121_ FPDMV 126_ KDVIG 131_ SYKKW 136_ CRSIL 141_ RRTSL 146_ ILARV 151_ FGLHL 156_ RLTSL 161_ HTMEF 166_ ALVKA 171_ LEPEE 176_ LDRVA 181_ LSNRM 186_ PMTGL 191_ LLMIL 196_ SLIYV 201_ KGRGA 206_ RESAV 211_ WNVLR 216_ ILGLR 221_ PWKKH 226_ STFGD 231_ VRKLI 236_ TEEFV 241_ QMNYL 246_ KYQRV 251_ PYVEP 256_ PEYEF 261_ FWGSR 266_ ASREI 271_ TKMQI 276_ MEFLA 281_ RVFKK 286_ DPQAW 291_ PSRYR 296_ EALEE 301_ ARALR 306_ EANPT 311_ AHYPR 316_SSVSE
1: Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Also functions as a transcription factor and directly binds to specific guanosine-rich DNA sequences (By similarity)