Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110)
1_MSRFF 6_ TTGSD 11_ SESES 16_ SLSGE 21_ ELVTK 26_ PVGGN 31_ YGKQP 36_ LLLSE 41_ DEEDT 46_ KRVVR 51_ SAKDK 56_ RFEEL 61_ TNLIR 66_ TIRNA 71_ MKIRD 76_ VTKCL 81_ EEFEL 86_ LGKAY 91_ GKAKS 96_ IVDKE 101_ GVPRF 106_ YIRIL 111_ ADLED 116_ YLNEL 121_ WEDKE 126_ GKKKM 131_ NKNNA 136_ KALST 141_ LRQKI 146_ RKYNR 151_ DFESH 156_ ITSYK 161_ QNPEQ 166_ SADED 171_ AEKNE 176_ EDSEG 181_ SSDED 186_ EDEDG 191_ VSAAT 196_ FLKKK 201_ SEAPS 206_ GESRK 211_ FLKKM 216_ DDEDE 221_ DSEDS 226_ EDDED 231_ WDTGS 236_ TSSDS 241_ DSEEE 246_ EGKQT 251_ ALASR 256_ FLKKA 261_ PTTDE 266_ DKKAA 271_ EKKRE 276_ DKAKK 281_ KHDRK 286_ SKRLD 291_ EEEED 296_ NEGGE 301_ WERVR 306_ GGVPL 311_ VKEKP 316_ KMFAK 321_ GTEIT 326_ HAVVI 331_ KKLNE 336_ ILQAR 341_ GKKGT 346_ DRAAQ 351_ IELLQ 356_ LLVQI 361_ AAENN 366_ LGEGV 371_ IVKIK 376_ FNIIA 381_ SLYDY 386_ NPNLA 391_ TYMKP 396_ EMWGK 401_ CLDCI 406_ NELMD 411_ ILFAN 416_ PNIFV 421_ GENIL 426_ EESEN 431_ LHNAD 436_ QPLRV 441_ RGCIL 446_ TLVER 451_ MDEEF 456_ TKIMQ 461_ NTDPH 466_ SQEYV 471_ EHLKD 476_ EAQVC 481_ AIIER 486_ VQRYL 491_ EEKGT 496_ TEEVC 501_ RIYLL 506_ RILHT 511_ YYKFD 516_ YKAHQ 521_ RQLTP 526_ PEGSS 531_ KSEQD 536_ QAENE 541_ GEDSA 546_ VLMER 551_ LCKYI 556_ YAKDR 561_ TDRIR 566_ TCAIL 571_ CHIYH 576_ HALHS 581_ RWYQA 586_ RDLML 591_ MSHLQ 596_ DNIQH 601_ ADPPV 606_ QILYN 611_ RTMVQ 616_ LGICA 621_ FRQGL 626_ TKDAH 631_ NALLD 636_ IQSSG 641_ RAKEL 646_ LGQGL 651_ LLRSL 656_ QERNQ 661_ EQEKV 666_ ERRRQ 671_ VPFHL 676_ HINLE 681_ LLECV 686_ YLVSA 691_ MLLEI 696_ PYMAA 701_ HESDA 706_ RRRMI 711_ SKQFH 716_ HQLRV 721_ GERQP 726_ LLGPP 731_ ESMRE 736_ HVVAA 741_ SKAMK 746_ MGDWK 751_ TCHSF 756_ IINEK 761_ MNGKV 766_ WDLFP 771_ EADKV 776_ RTMLV 781_ RKIQE 786_ ESLRT 791_ YLFTY 796_ SSVYD 801_ SISME 806_ TLSDM 811_ FELDL 816_ PTVHS 821_ IISKM 826_ IINEE 831_ LMASL 836_ DQPTQ 841_ TVVMH 846_ RTEPT 851_ AQQNL 856_ ALQLA 861_ EKLGS 866_ LVENN 871_ ERVFD 876_ HKQGT 881_ YGGYF 886_ RDQKD 891_ GYRKN 896_ EGYMR 901_ RGGYR 906_QQQSQ
1: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773)