SPRY domain-containing SOCS box protein 2 (SSB-2) (Gene-rich cluster protein C9)
1_MGQTA 6_ LAGGS 11_ SSTPT 16_ PQALY 21_ PDLSC 26_ PEGLE 31_ ELLSA 36_ PPPDL 41_ GAQRR 46_ HGWNP 51_ KDCSE 56_ NIEVK 61_ EGGLY 66_ FERRP 71_ VAQST 76_ DGARG 81_ KRGYS 86_ RGLHA 91_ WEISW 96_ PLEQR 101_ GTHAV 106_ VGVAT 111_ ALAPL 116_ QTDHY 121_ AALLG 126_ SNSES 131_ WGWDI 136_ GRGKL 141_ YHQSK 146_ GPGAP 151_ QYPAG 156_ TQGEQ 161_ LEVPE 166_ RLLVV 171_ LDMEE 176_ GTLGY 181_ AIGGT 186_ YLGPA 191_ FRGLK 196_ GRTLY 201_ PAVSA 206_ VWGQC 211_ QVRIR 216_ YLGER 221_ RAEPH 226_ SLLHL 231_ SRLCV 236_ RHNLG 241_ DTRLG 246_ QVSAL 251_ PLPPA 256_MKRYL
1: Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199876). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876)