Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity)
1_MAQNL 6_ KDLAG 11_ RLPAG 16_ PRGMG 21_ TALKL 26_ LLGAG 31_ AVAYG 36_ VRESV 41_ FTVEG 46_ GHRAI 51_ FFNRI 56_ GGVQQ 61_ DTILA 66_ EGLHF 71_ RIPWF 76_ QYPII 81_ YDIRA 86_ RPRKI 91_ SSPTG 96_ SKDLQ 101_ MVNIS 106_ LRVLS 111_ RPNAQ 116_ ELPSM 121_ YQRLG 126_ LDYEE 131_ RVLPS 136_ IVNEV 141_ LKSVV 146_ AKFNA 151_ SQLIT 156_ QRAQV 161_ SLLIR 166_ RELTE 171_ RAKDF 176_ SLILD 181_ DVAIT 186_ ELSFS 191_ REYTA 196_ AVEAK 201_ QVAQQ 206_ EAQRA 211_ QFLVE 216_ KAKQE 221_ QRQKI 226_ VQAEG 231_ EAEAA 236_ KMLGE 241_ ALSKN 246_ PGYIK 251_ LRKIR 256_ AAQNI 261_ SKTIA 266_ TSQNR 271_ IYLTA 276_ DNLVL 281_ NLQDE 286_ SFTRG 291_SDSLI
1: Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus
2: In the mitochondria, together with PHB, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Also regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration (PubMed:11302691, PubMed:20959514). Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity (PubMed:11302691, PubMed:20959514). Has a key role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (PubMed:28017329). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117)
3: In the nucleus, serves as transcriptional co-regulator (Probable). Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity (By similarity)
4: In the plasma membrane, is involved in IGFBP6-induced cell migration (PubMed:24003225). Cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity)
5: (Microbial infection) Involved in human enterovirus 71/EV-71 infection by enhancing the autophagy mechanism during the infection