Sodium-coupled neutral amino acid transporter 3 (N-system amino acid transporter 1) (Na(+)-coupled neutral amino acid transporter 3) (Solute carrier family 38 member 3) (System N amino acid transporter 1)
1_MEAPL 6_ QTEMV 11_ ELVPN 16_ GKHSE 21_ GLLPV 26_ ITPMA 31_ GNQRV 36_ EDPAR 41_ SCMEG 46_ KSFLQ 51_ KSPSK 56_ EPHFT 61_ DFEGK 66_ TSFGM 71_ SVFNL 76_ SNAIM 81_ GSGIL 86_ GLAYA 91_ MANTG 96_ IILFL 101_ FLLTA 106_ VALLS 111_ SYSIH 116_ LLLKS 121_ SGVVG 126_ IRAYE 131_ QLGYR 136_ AFGTP 141_ GKLAA 146_ ALAIT 151_ LQNIG 156_ AMSSY 161_ LYIIK 166_ SELPL 171_ VIQTF 176_ LNLEE 181_ KTSDW 186_ YMNGN 191_ YLVIL 196_ VSVTI 201_ ILPLA 206_ LMRQL 211_ GYLGY 216_ SSGFS 221_ LSCMV 226_ FFLIA 231_ VIYKK 236_ FHVPC 241_ PLPPN 246_ FNNTT 251_ GNFSH 256_ VEIVK 261_ EKVQL 266_ QVEPE 271_ ASAFC 276_ TPSYF 281_ TLNSQ 286_ TAYTI 291_ PIMAF 296_ AFVCH 301_ PEVLP 306_ IYTEL 311_ KDPSK 316_ KKMQH 321_ ISNLS 326_ IAVMY 331_ IMYFL 336_ AALFG 341_ YLTFY 346_ NGVES 351_ ELLHT 356_ YSKVD 361_ PFDVL 366_ ILCVR 371_ VAVLT 376_ AVTLT 381_ VPIVL 386_ FPVRR 391_ AIQQM 396_ LFPNQ 401_ EFSWL 406_ RHVLI 411_ AVGLL 416_ TCINL 421_ LVIFA 426_ PNILG 431_ IFGVI 436_ GATSA 441_ PFLIF 446_ IFPAI 451_ FYFRI 456_ MPTEK 461_ EPARS 466_ TPKIL 471_ ALCFA 476_ MLGFL 481_ LMTMS 486_ LSFII 491_ IDWAS 496_GTSRH
1: Symporter that cotransports specific neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:10823827). Mainly participates in the glutamate-GABA-glutamine cycle in brain where it transports L-glutamine from astrocytes in the intercellular space for the replenishment of both neurotransmitters glutamate and gamma-aminobutyric acid (GABA) in neurons and also functions as the major influx transporter in ganglion cells mediating the uptake of glutamine (By similarity). The transport activity is specific for L-glutamine, L-histidine and L-asparagine (PubMed:10823827). The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (By similarity). The transport is pH dependent, saturable, Li(+) tolerant and functions in both direction depending on the concentration gradients of its substrates and cotransported ions (PubMed:10823827). Also mediates an amino acid-gated H(+) conductance that is not stoichiometrically coupled to the amino acid transport but which influences the ionic gradients that drive the amino acid transport (By similarity). In addition, may play a role in nitrogen metabolism, amino acid homeostasis, glucose metabolism and renal ammoniagenesis (By similarity)