Homeobox protein CDX-2 (CDX-3) (Caudal-type homeobox protein 2)
1_MYVSY 6_ LLDKD 11_ VSMYP 16_ SSVRH 21_ SGGLN 26_ LAPQN 31_ FVSPP 36_ QYPDY 41_ GGYHV 46_ AAAAA 51_ AAANL 56_ DSAQS 61_ PGPSW 66_ PAAYG 71_ APLRE 76_ DWNGY 81_ APGGA 86_ AAAAN 91_ AVAHG 96_ LNGGS 101_ PAAAM 106_ GYSSP 111_ ADYHP 116_ HHHPH 121_ HHPHH 126_ PAAAP 131_ SCASG 136_ LLQTL 141_ NPGPP 146_ GPAAT 151_ AAAEQ 156_ LSPGG 161_ QRRNL 166_ CEWMR 171_ KPAQQ 176_ SLGSQ 181_ VKTRT 186_ KDKYR 191_ VVYTD 196_ HQRLE 201_ LEKEF 206_ HYSRY 211_ ITIRR 216_ KAELA 221_ ATLGL 226_ SERQV 231_ KIWFQ 236_ NRRAK 241_ ERKIN 246_ KKKLQ 251_ QQQQQ 256_ QPPQP 261_ PPPPP 266_ QPPQP 271_ QPGPL 276_ RSVPE 281_ PLSPV 286_ SSLQA 291_ SVPGS 296_ VPGVL 301_ GPTGG 306_VLNPT
1: Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium (By similarity). Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription (By similarity). Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription (By similarity). Binds to and activates transcription of LPH (By similarity). Activates transcription of CLDN2 and intestinal mucin MUC2 (By similarity). Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription (By similarity). Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (PubMed:28473536)