COP9 signalosome complex subunit 8 (SGN8) (Signalosome subunit 8) (COP9 homolog) (hCOP9) (JAB1-containing signalosome subunit 8)
1_MPVAV 6_ MAESA 11_ FSFKK 16_ LLDQC 21_ ENQEL 26_ EAPGG 31_ IATPP 36_ VYGQL 41_ LALYL 46_ LHNDM 51_ NNARY 56_ LWKRI 61_ PPAIK 66_ SANSE 71_ LGGIW 76_ SVGQR 81_ IWQRD 86_ FPGIY 91_ TTINA 96_ HQWSE 101_ TVQPI 106_ MEALR 111_ DATRR 116_ RAFAL 121_ VSQAY 126_ TSIIA 131_ DDFAA 136_ FVGLP 141_ VEEAV 146_ KGILE 151_ QGWQA 156_ DSTTR 161_ MVLPR 166_ KPVAG 171_ ALDVS 176_ FNKFI 181_ PLSEP 186_ APVPP 191_ IPNEQ 196_ QLARL 201_TDYVA
1: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively