Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase)
1_MLERP 6_ PALAM 11_ PMPTE 16_ GTPPP 21_ LSGTP 26_ IPVPA 31_ YFRHA 36_ EPGFS 41_ LKRPR 46_ GLSRS 51_ LPPPP 56_ PAKGS 61_ IPISR 66_ LFPPR 71_ TPGWH 76_ QLQPR 81_ RVSFR 86_ GEASE 91_ TLQSP 96_ GYDPS 101_ RPESF 106_ FQQSF 111_ QRLSR 116_ LGHGS 121_ YGEVF 126_ KVRSK 131_ EDGRL 136_ YAVKR 141_ SMSPF 146_ RGPKD 151_ RARKL 156_ AEVGS 161_ HEKVG 166_ QHPCC 171_ VRLEQ 176_ AWEEG 181_ GILYL 186_ QTELC 191_ GPSLQ 196_ QHCEA 201_ WGASL 206_ PEAQV 211_ WGYLR 216_ DTLLA 221_ LAHLH 226_ SQGLV 231_ HLDVK 236_ PANIF 241_ LGPRG 246_ RCKLG 251_ DFGLL 256_ VELGT 261_ AGAGE 266_ VQEGD 271_ PRYMA 276_ PELLQ 281_ GSYGT 286_ AADVF 291_ SLGLT 296_ ILEVA 301_ CNMEL 306_ PHGGE 311_ GWQQL 316_ RQGYL 321_ PPEFT 326_ AGLSS 331_ ELRSV 336_ LVMML 341_ EPDPK 346_ LRATA 351_ EALLA 356_ LPVLR 361_ QPRAW 366_ GVLWC 371_ MAAEA 376_ LSRGW 381_ ALWQA 386_ LLALL 391_ CWLWH 396_ GLAHP 401_ ASWLQ 406_ PLGPP 411_ ATPPG 416_ SPPCS 421_ LLLDS 426_ SLSSN 431_ WDDDS 436_ LGPSL 441_ SPEAV 446_ LARTV 451_ GSTST 456_ PRSRC 461_ TPRDA 466_ LDLSD 471_ INSEP 476_ PRGSF 481_ PSFEP 486_ RNLLS 491_LFEDT
1: Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins (PubMed:10373560, PubMed:10504341, PubMed:9001210, PubMed:9268380). Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation (PubMed:9001210, PubMed:9268380). May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:9001210, PubMed:9268380)