Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)
1_MSTEA 6_ DEGIT 11_ FSVPP 16_ FAPSG 21_ FCTIP 26_ EGGIC 31_ RRGGA 36_ AAVGE 41_ GEEHQ 46_ LPPPP 51_ PGSFW 56_ NVESA 61_ AAPGI 66_ GCPAA 71_ TSSSS 76_ ATRGR 81_ GSSVG 86_ GGSRR 91_ TTVAY 96_ VINEA 101_ SQGQL 106_ VVAES 111_ EALQS 116_ LREAC 121_ ETVGA 126_ TLETL 131_ HFGKL 136_ DFGET 141_ TVLDR 146_ FYNAD 151_ IAVVE 156_ MSDAF 161_ RQPSL 166_ FYHLG 171_ VRESF 176_ SMANN 181_ IILYC 186_ DTNSD 191_ SLQSL 196_ KEIIC 201_ QKNTM 206_ CTGNY 211_ TFVPY 216_ MITPH 221_ NKVYC 226_ CDSSF 231_ MKGLT 236_ ELMQP 241_ NFELL 246_ LGPIC 251_ LPLVD 256_ RFIQL 261_ LKVAQ 266_ ASSSQ 271_ YFRES 276_ ILNDI 281_ RKARN 286_ LYTGK 291_ ELAAE 296_ LARIR 301_ QRVDN 306_ IEVLT 311_ ADIVI 316_ NLLLS 321_ YRDIQ 326_ DYDSI 331_ VKLVE 336_ TLEKL 341_ PTFDL 346_ ASHHH 351_ VKFHY 356_ AFALN 361_ RRNLP 366_ GDRAK 371_ ALDIM 376_ IPMVQ 381_ SEGQV 386_ ASDMY 391_ CLVGR 396_ IYKDM 401_ FLDSN 406_ FTDTE 411_ SRDHG 416_ ASWFK 421_ KAFES 426_ EPTLQ 431_ SGINY 436_ AVLLL 441_ AAGHQ 446_ FESSF 451_ ELRKV 456_ GVKLS 461_ SLLGK 466_ KGNLE 471_ KLQSY 476_ WEVGF 481_ FLGAS 486_ VLAND 491_ HMRVI 496_ QASEK 501_ LFKLK 506_ TPAWY 511_ LKSIV 516_ ETILI 521_ YKHFV 526_ KLTTE 531_ QPVAK 536_ QELVD 541_ FWMDF 546_ LVEAT 551_ KTDVT 556_ VVRFP 561_ VLILE 566_ PTKIY 571_ QPSYL 576_ SINNE 581_ VEEKT 586_ ISIWH 591_ VLPDD 596_ KKGIH 601_ EWNFS 606_ ASSVR 611_ GVSIS 616_ KFEER 621_ CCFLY 626_ VLHNS 631_ DDFQI 636_ YFCTE 641_ LHCKK 646_ FFEMV 651_ NTITE 656_ EKGRS 661_ TEEGD 666_ CESDL 671_ LEYDY 676_ EYDEN 681_ GDRVV 686_ LGKGT 691_ YGIVY 696_ AGRDL 701_ SNQVR 706_ IAIKE 711_ IPERD 716_ SRYSQ 721_ PLHEE 726_ IALHK 731_ HLKHK 736_ NIVQY 741_ LGSFS 746_ ENGFI 751_ KIFME 756_ QVPGG 761_ SLSAL 766_ LRSKW 771_ GPLKD 776_ NEQTI 781_ GFYTK 786_ QILEG 791_ LKYLH 796_ DNQIV 801_ HRDIK 806_ GDNVL 811_ INTYS 816_ GVLKI 821_ SDFGT 826_ SKRLA 831_ GINPC 836_ TETFT 841_ GTLQY 846_ MAPEI 851_ IDKGP 856_ RGYGK 861_ AADIW 866_ SLGCT 871_ IIEMA 876_ TGKPP 881_ FYELG 886_ EPQAA 891_ MFKVG 896_ MFKVH 901_ PEIPE 906_ SMSAE 911_ AKAFI 916_ LKCFE 921_ PDPDK 926_ RACAN 931_ DLLVD 936_ EFLKV 941_ SSKKK 946_ KTQPK 951_ LSALS 956_ AGSNE 961_ YLRSI 966_ SLPVP 971_ VLVED 976_ TSSSS 981_ EYGSV 986_ SPDTE 991_ LKVDP 996_ FSFKT 1001_ RAKSC 1006_ GERDV 1011_ KGIRT 1016_ LFLGI 1021_ PDENF 1026_ EDHSA 1031_ PPSPE 1036_ EKDSG 1041_ FFMLR 1046_ KDSER 1051_ RATLH 1056_ RILTE 1061_ DQDKI 1066_ VRNLM 1071_ ESLAQ 1076_ GAEEP 1081_ KLKWE 1086_ HITTL 1091_ IASLR 1096_ EFVRS 1101_ TDRKI 1106_ IATTL 1111_ SKLKL 1116_ ELDFD 1121_ SHGIS 1126_ QVQVV 1131_ LFGFQ 1136_ DAVNK 1141_ VLRNH 1146_ NIKPH 1151_ WMFAL 1156_ DSIIR 1161_ KAVQT 1166_ AITIL 1171_ VPELR 1176_ PHFSL 1181_ ASESD 1186_ TADQE 1191_ DLDVE 1196_ DDHEE 1201_ QPSNQ 1206_ TVRRP 1211_ QAVIE 1216_ DAVAT 1221_ SGVST 1226_ LSSTV 1231_ SHDSQ 1236_ SAHRS 1241_ LNVQL 1246_ GRMKI 1251_ ETNRL 1256_ LEELV 1261_ RKEKE 1266_ LQALL 1271_ HRAIE 1276_ EKDQE 1281_ IKHLK 1286_ LKSQP 1291_ IEIPE 1296_ LPVFH 1301_ LNSSG 1306_ TNTED 1311_ SELTD 1316_ WLRVN 1321_ GADED 1326_ TISRF 1331_ LAEDY 1336_ TLLDV 1341_ LYYVT 1346_ RDDLK 1351_ CLRLR 1356_ GGMLC 1361_ TLWKA 1366_IIDFR
1: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1)