Zinc finger protein Gfi-1 (Growth factor independent protein 1) (Zinc finger protein 163)
1_MPRSF 6_ LVKSK 11_ KAHSY 16_ HQPRS 21_ PGPDY 26_ SLRLE 31_ NVPAP 36_ SRADS 41_ TSNAG 46_ GAKAE 51_ PRDRL 56_ SPESQ 61_ LTEAP 66_ DRASA 71_ SPDSC 76_ EGSVC 81_ ERSSE 86_ FEDFW 91_ RPPSP 96_ SASPA 101_ SEKSM 106_ CPSLD 111_ EAQPF 116_ PLPFK 121_ PYSWS 126_ GLAGS 131_ DLRHL 136_ VQSYR 141_ PCGAL 146_ ERGAG 151_ LGLFC 156_ EPAPE 161_ PGHPA 166_ ALYGP 171_ KRAAG 176_ GAGAG 181_ APGSC 186_ SAGAG 191_ ATAGP 196_ GLGLY 201_ GDFGS 206_ AAAGL 211_ YERPT 216_ AAAGL 221_ LYPER 226_ GHGLH 231_ ADKGA 236_ GVKVE 241_ SELLC 246_ TRLLL 251_ GGGSY 256_ KCIKC 261_ SKVFS 266_ TPHGL 271_ EVHVR 276_ RSHSG 281_ TRPFA 286_ CEMCG 291_ KTFGH 296_ AVSLE 301_ QHKAV 306_ HSQER 311_ SFDCK 316_ ICGKS 321_ FKRSS 326_ TLSTH 331_ LLIHS 336_ DTRPY 341_ PCQYC 346_ GKRFH 351_ QKSDM 356_ KKHTF 361_ IHTGE 366_ KPHKC 371_ QVCGK 376_ AFSQS 381_ SNLIT 386_ HSRKH 391_ TGFKP 396_ FGCDL 401_ CGKGF 406_ QRKVD 411_ LRRHR 416_ETQHG
1: Transcription repressor essential for hematopoiesis (PubMed:11060035, PubMed:17197705, PubMed:17646546, PubMed:18805794, PubMed:19164764, PubMed:20190815, PubMed:8754800). Functions in a cell-context and development-specific manner (PubMed:11060035, PubMed:17197705, PubMed:17646546, PubMed:18805794, PubMed:19164764, PubMed:20190815, PubMed:8754800). Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes (PubMed:11060035, PubMed:17197705, PubMed:17646546, PubMed:18805794, PubMed:19164764, PubMed:20190815, PubMed:8754800). Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (PubMed:16287849). Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development (PubMed:12778173). Inhibits SPI1 transcriptional activity at macrophage-specific genes, repressing macrophage differentiation of myeloid progenitor cells and promoting granulocyte commitment (By similarity). Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling (By similarity). Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA (PubMed:20547752). Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth (PubMed:19026687). Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters (PubMed:16287849). Required for the maintenance of inner ear hair cells (By similarity). In addition to its role in transcription, acts as a substrate adapter for PRMT1 in the DNA damage response: facilitates the recognition of TP53BP1 and MRE11 substrates by PRMT1, promoting their methylation and the DNA damage response (PubMed:29651020)