Monoglyceride lipase (MGL) (EC 3.1.1.23) (HU-K5) (Lysophospholipase homolog) (Lysophospholipase-like) (Monoacylglycerol lipase) (MAGL)
1_MPEES 6_ SPRRT 11_ PQSIP 16_ YQDLP 21_ HLVNA 26_ DGQYL 31_ FCRYW 36_ KPTGT 41_ PKALI 46_ FVSHG 51_ AGEHS 56_ GRYEE 61_ LARML 66_ MGLDL 71_ LVFAH 76_ DHVGH 81_ GQSEG 86_ ERMVV 91_ SDFHV 96_ FVRDV 101_ LQHVD 106_ SMQKD 111_ YPGLP 116_ VFLLG 121_ HSMGG 126_ AIAIL 131_ TAAER 136_ PGHFA 141_ GMVLI 146_ SPLVL 151_ ANPES 156_ ATTFK 161_ VLAAK 166_ VLNLV 171_ LPNLS 176_ LGPID 181_ SSVLS 186_ RNKTE 191_ VDIYN 196_ SDPLI 201_ CRAGL 206_ KVCFG 211_ IQLLN 216_ AVSRV 221_ ERALP 226_ KLTVP 231_ FLLLQ 236_ GSADR 241_ LCDSK 246_ GAYLL 251_ MELAK 256_ SQDKT 261_ LKIYE 266_ GAYHV 271_ LHKEL 276_ PEVTN 281_ SVFHE 286_ INMWV 291_ SQRTA 296_TAGTA
1: Converts monoacylglycerides to free fatty acids and glycerol (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (PubMed:20079333)