Pituitary homeobox 2 (ALL1-responsive protein ARP1) (Homeobox protein PITX2) (Paired-like homeodomain transcription factor 2) (RIEG bicoid-related homeobox transcription factor) (Solurshin)
1_METNC 6_ RKLVS 11_ ACVQL 16_ GVQPA 21_ AVECL 26_ FSKDS 31_ EIKKV 36_ EFTDS 41_ PESRK 46_ EAASS 51_ KFFPR 56_ QHPGA 61_ NEKDK 66_ SQQGK 71_ NEDVG 76_ AEDPS 81_ KKKRQ 86_ RRQRT 91_ HFTSQ 96_ QLQEL 101_ EATFQ 106_ RNRYP 111_ DMSTR 116_ EEIAV 121_ WTNLT 126_ EARVR 131_ VWFKN 136_ RRAKW 141_ RKRER 146_ NQQAE 151_ LCKNG 156_ FGPQF 161_ NGLMQ 166_ PYDDM 171_ YPGYS 176_ YNNWA 181_ AKGLT 186_ SASLS 191_ TKSFP 196_ FFNSM 201_ NVNPL 206_ SSQSM 211_ FSPPN 216_ SISSM 221_ SMSSS 226_ MVPSA 231_ VTGVP 236_ GSSLN 241_ SLNNL 246_ NNLSS 251_ PSLNS 256_ AVPTP 261_ ACPYA 266_ PPTPP 271_ YVYRD 276_ TCNSS 281_ LASLR 286_ LKAKQ 291_ HSSFG 296_ YASVQ 301_ NPASN 306_ LSACQ 311_YAVDR
1: May play a role in myoblast differentiation. When unphosphorylated, associates with an ELAVL1-containing complex, which stabilizes cyclin mRNA and ensuring cell proliferation. Phosphorylation by AKT2 impairs this association, leading to CCND1 mRNA destabilization and progression towards differentiation
2: Involved in the establishment of left-right asymmetry in the developing embryo