Lysosomal-trafficking regulator (Beige homolog)
1_MSTDS 6_ NSLAR 11_ EFLTD 16_ VNRLC 21_ NAVVQ 26_ RVEAR 31_ EEEEE 36_ ETHMA 41_ TLGQY 46_ LVHGR 51_ GFLLL 56_ TKLNS 61_ IIDQA 66_ LTCRE 71_ ELLTL 76_ LLSLL 81_ PLVWK 86_ IPVQE 91_ EKATD 96_ FNLPL 101_ SADII 106_ LTKEK 111_ NSSSQ 116_ RSTQE 121_ KLHLE 126_ GSALS 131_ SQVSA 136_ KVNVF 141_ RKSRR 146_ QRKIT 151_ HRYSV 156_ RDARK 161_ TQLST 166_ SDSEA 171_ NSDEK 176_ GIAMN 181_ KHRRP 186_ HLLHH 191_ FLTSF 196_ PKQDH 201_ PKAKL 206_ DRLAT 211_ KEQTP 216_ PDAMA 221_ LENSR 226_ EIIPR 231_ QGSNT 236_ DILSE 241_ PAALS 246_ VISNM 251_ NNSPF 256_ DLCHV 261_ LLSLL 266_ EKVCK 271_ FDVTL 276_ NHNSP 281_ LAASV 286_ VPTLT 291_ EFLAG 296_ FGDCC 301_ SLSDN 306_ LESRV 311_ VSAGW 316_ TEEPV 321_ ALIQR 326_ MLFRT 331_ VLHLL 336_ SVDVS 341_ TAEMM 346_ PENLR 351_ KNLTE 356_ LLRAA 361_ LKIRI 366_ CLEKQ 371_ PDPFA 376_ PRQKK 381_ TLQEV 386_ QEDFV 391_ FSKYR 396_ HRALL 401_ LPELL 406_ EGVLQ 411_ ILICC 416_ LQSAA 421_ SNPFY 426_ FSQAM 431_ DLVQE 436_ FIQHH 441_ GFNLF 446_ ETAVL 451_ QMEWL 456_ VLRDG 461_ VPPEA 466_ SEHLK 471_ ALINS 476_ VMKIM 481_ STVKK 486_ VKSEQ 491_ LHHSM 496_ CTRKR 501_ HRRCE 506_ YSHFM 511_ HHHRD 516_ LSGLL 521_ VSAFK 526_ NQVSK 531_ NPFEE 536_ TADGD 541_ VYYPE 546_ RCCCI 551_ AVCAH 556_ QCLRL 561_ LQQAS 566_ LSSTC 571_ VQILS 576_ GVHNI 581_ GICCC 586_ MDPKS 591_ VIIPL 596_ LHAFK 601_ LPALK 606_ NFQQH 611_ ILNIL 616_ NKLIL 621_ DQLGG 626_ AEISP 631_ KIKKA 636_ ACNIC 641_ TVDSD 646_ QLAQL 651_ EETLQ 656_ GNLCD 661_ AELSS 666_ SLSSP 671_ SYRFQ 676_ GILPS 681_ SGSED 686_ LLWKW 691_ DALKA 696_ YQNFV 701_ FEEDR 706_ LHSIQ 711_ IANHI 716_ CNLIQ 721_ KGNIV 726_ VQWKL 731_ YNYIF 736_ NPVLQ 741_ RGVEL 746_ AHHCQ 751_ HLSVT 756_ SAQSH 761_ VCSHH 766_ NQCLP 771_ QDVLQ 776_ IYVKT 781_ LPILL 786_ KSRVI 791_ RDLFL 796_ SCNGV 801_ SQIIE 806_ LNCLN 811_ GIRSH 816_ SLKAF 821_ ETLII 826_ SLGEQ 831_ QKDAS 836_ VPDID 841_ GIDIE 846_ QKELS 851_ SVHVG 856_ TSFHH 861_ QQAYS 866_ DSPQS 871_ LSKFY 876_ AGLKE 881_ AYPKR 886_ RKTVN 891_ QDVHI 896_ NTINL 901_ FLCVA 906_ FLCVS 911_ KEAES 916_ DRESA 921_ NDSED 926_ TSGYD 931_ STASE 936_ PLSHM 941_ LPCIS 946_ LESLV 951_ LPSPE 956_ HMHQA 961_ ADIWS 966_ MCRWI 971_ YMLSS 976_ VFQKQ 981_ FYRLG 986_ GFRVC 991_ HKLIF 996_ MIIQK 1001_ LFRSH 1006_ KEEQG 1011_ KKEGD 1016_ TSVNE 1021_ NQDLN 1026_ RISQP 1031_ KRTMK 1036_ EDLLS 1041_ LAIKS 1046_ DPIPS 1051_ ELGSL 1056_ KKSAD 1061_ SLGKL 1066_ ELQHI 1071_ SSINV 1076_ EEVSA 1081_ TEAAP 1086_ EEAKL 1091_ FTSQE 1096_ SETSL 1101_ QSIRL 1106_ LEALL 1111_ AICLH 1116_ GARTS 1121_ QQKME 1126_ LELPN 1131_ QNLSV 1136_ ESILF 1141_ EMRDH 1146_ LSQSK 1151_ VIETQ 1156_ LAKPL 1161_ FDALL 1166_ RVALG 1171_ NYSAD 1176_ FEHND 1181_ AMTEK 1186_ SHQSA 1191_ EELSS 1196_ QPGDF 1201_ SEEAE 1206_ DSQCC 1211_ SFKLL 1216_ VEEEG 1221_ YEADS 1226_ ESNPE 1231_ DGETQ 1236_ DDGVD 1241_ LKSET 1246_ EGFSA 1251_ SSSPN 1256_ DLLEN 1261_ LTQGE 1266_ IIYPE 1271_ ICMLE 1276_ LNLLS 1281_ ASKAK 1286_ LDVLA 1291_ HVFES 1296_ FLKII 1301_ RQKEK 1306_ NVFLL 1311_ MQQGT 1316_ VKNLL 1321_ GGFLS 1326_ ILTQD 1331_ DSDFQ 1336_ ACQRV 1341_ LVDLL 1346_ VSLMS 1351_ SRTCS 1356_ EELTL 1361_ LLRIF 1366_ LEKSP 1371_ CTKIL 1376_ LLGIL 1381_ KIIES 1386_ DTTMS 1391_ PSQYL 1396_ TFPLL 1401_ HAPNL 1406_ SNGVS 1411_ SQKYP 1416_ GILNS 1421_ KAMGL 1426_ LRRAR 1431_ VSRSK 1436_ KEADR 1441_ ESFPH 1446_ RLLSS 1451_ WHIAP 1456_ VHLPL 1461_ LGQNC 1466_ WPHLS 1471_ EGFSV 1476_ SLWFN 1481_ VECIH 1486_ EAEST 1491_ TEKGK 1496_ KIKKR 1501_ NKSLI 1506_ LPDSS 1511_ FDGTE 1516_ SDRPE 1521_ GAEYI 1526_ NPGER 1531_ LIEEG 1536_ CIHII 1541_ SLGSK 1546_ ALMIQ 1551_ VWADP 1556_ HNATL 1561_ IFRVC 1566_ MDSND 1571_ DMKAV 1576_ LLAQV 1581_ ESQEN 1586_ IFLPS 1591_ KWQHL 1596_ VLTYL 1601_ QQPQG 1606_ KRRIH 1611_ GKISI 1616_ WVSGQ 1621_ RKPDV 1626_ TLDFM 1631_ LPRKT 1636_ SLSSD 1641_ SNKTF 1646_ CMIGH 1651_ CLSSQ 1656_ EEFLQ 1661_ LAGKW 1666_ DLGNL 1671_ LLFNG 1676_ AKVGS 1681_ QEAFY 1686_ LYACG 1691_ PNHTS 1696_ VMPCK 1701_ YGKPV 1706_ NDYSK 1711_ YINKE 1716_ ILRCE 1721_ QIREL 1726_ FMTKK 1731_ DVDIG 1736_ LLIES 1741_ LSVVY 1746_ TTYCP 1751_ AQYTI 1756_ YEPVI 1761_ RLKGQ 1766_ MKTQL 1771_ SQRPF 1776_ SSKEV 1781_ QSILL 1786_ EPHHL 1791_ KNLQP 1796_ TEYKT 1801_ IQGIL 1806_ HEIGG 1811_ TGIFV 1816_ FLFAR 1821_ VVELS 1826_ SCEET 1831_ QALAL 1836_ RVILS 1841_ LIKYN 1846_ QQRVH 1851_ ELENC 1856_ NGLSM 1861_ IHQVL 1866_ IKQKC 1871_ IVGFY 1876_ ILKTL 1881_ LEGCC 1886_ GEDII 1891_ YMNEN 1896_ GEFKL 1901_ DVDSN 1906_ AIIQD 1911_ VKLLE 1916_ ELLLD 1921_ WKIWS 1926_ KAEQG 1931_ VWETL 1936_ LAALE 1941_ VLIRA 1946_ DHHQQ 1951_ MFNIK 1956_ QLLKA 1961_ QVVHH 1966_ FLLTC 1971_ QVLQE 1976_ YKEGQ 1981_ LTPMP 1986_ REVCR 1991_ SFVKI 1996_ IAEVL 2001_ GSPPD 2006_ LELLT 2011_ IIFNF 2016_ LLAVH 2021_ PPTNT 2026_ YVCHN 2031_ PTNFY 2036_ FSLHI 2041_ DGKIF 2046_ QEKVR 2051_ SIMYL 2056_ RHSSS 2061_ GGRSL 2066_ MSPGF 2071_ MVISP 2076_ SGFTA 2081_ SPYEG 2086_ ENSSN 2091_ IIPQQ 2096_ MAAHM 2101_ LRSRS 2106_ LPAFP 2111_ TSSLL 2116_ TQSQK 2121_ LTGSL 2126_ GCSID 2131_ RLQNI 2136_ ADTYV 2141_ ATQSK 2146_ KQNSL 2151_ GSSDT 2156_ LKKGK 2161_ EDAFI 2166_ SSCES 2171_ AKTVC 2176_ EMEAV 2181_ LSAQV 2186_ SVSDV 2191_ PKGVL 2196_ GFPVV 2201_ KADHK 2206_ QLGAE 2211_ PRSED 2216_ DSPGD 2221_ ESCPR 2226_ RPDYL 2231_ KGLAS 2236_ FQRSH 2241_ STIAS 2246_ LGLAF 2251_ PSQNG 2256_ SAAVG 2261_ RWPSL 2266_ VDRNT 2271_ DDWEN 2276_ FAYSL 2281_ GYEPN 2286_ YNRTA 2291_ SAHSV 2296_ TEDCL 2301_ VPICC 2306_ GLYEL 2311_ LSGVL 2316_ LILPD 2321_ VLLED 2326_ VMDKL 2331_ IQADT 2336_ LLVLV 2341_ NHPSP 2346_ AIQQG 2351_ VIKLL 2356_ DAYFA 2361_ RASKE 2366_ QKDKF 2371_ LKNRG 2376_ FSLLA 2381_ NQLYL 2386_ HRGTQ 2391_ ELLEC 2396_ FIEMF 2401_ FGRHI 2406_ GLDEE 2411_ FDLED 2416_ VRNMG 2421_ LFQKW 2426_ SVIPI 2431_ LGLIE 2436_ TSLYD 2441_ NILLH 2446_ NALLL 2451_ LLQIL 2456_ NSCSK 2461_ VADML 2466_ LDNGL 2471_ LYVLC 2476_ NTVAA 2481_ LNGLE 2486_ KNIPM 2491_ SEYKL 2496_ LACDI 2501_ QQLFI 2506_ AVTIH 2511_ ACSSS 2516_ GSQYF 2521_ RVIED 2526_ LIVML 2531_ GYLQN 2536_ SKNKR 2541_ TQNMA 2546_ VALQL 2551_ RVLQA 2556_ AMEFI 2561_ RTTAN 2566_ HDSEN 2571_ LTDSL 2576_ QSPSA 2581_ PHHAV 2586_ VQKRK 2591_ SIAGP 2596_ RKFPL 2601_ AQTES 2606_ LLMKM 2611_ RSVAN 2616_ DELHV 2621_ MMQRR 2626_ MSQEN 2631_ PSQAT 2636_ ETELA 2641_ QRLQR 2646_ LTVLA 2651_ VNRII 2656_ YQEFN 2661_ SDIID 2666_ ILRTP 2671_ ENVTQ 2676_ SKTSV 2681_ FQTEI 2686_ SEENI 2691_ HHEQS 2696_ SVFNP 2701_ FQKEI 2706_ FTYLV 2711_ EGFKV 2716_ SIGSS 2721_ KASGS 2726_ KQQWT 2731_ KILWS 2736_ CKETF 2741_ RMQLG 2746_ RLLVH 2751_ ILSPA 2756_ HAAQE 2761_ RKQIF 2766_ EIVHE 2771_ PNHQE 2776_ ILRDC 2781_ LSPSL 2786_ QHGAK 2791_ LVLYL 2796_ SELIH 2801_ NHQGE 2806_ LTEEE 2811_ LGTAE 2816_ LLMNA 2821_ LKLCG 2826_ HKCIP 2831_ PSAST 2836_ KADLI 2841_ KMIKE 2846_ EQKKY 2851_ ETEEG 2856_ VNKAA 2861_ WQKTV 2866_ NNNQQ 2871_ SLFQR 2876_ LDSKS 2881_ KDISK 2886_ IAADI 2891_ TQAVS 2896_ LSQGN 2901_ ERKKV 2906_ IQHIR 2911_ GMYKV 2916_ DLSAS 2921_ RHWQE 2926_ LIQQL 2931_ THDRA 2936_ VWYDP 2941_ IYYPT 2946_ SWQLD 2951_ PTEGP 2956_ NRERR 2961_ RLQRC 2966_ YLTIP 2971_ NKYLL 2976_ RDRQK 2981_ SEDVV 2986_ KPPLS 2991_ YLFED 2996_ KTHSS 3001_ FSSTV 3006_ KDKAA 3011_ SESIR 3016_ VNRRC 3021_ ISVAP 3026_ SRETA 3031_ GELLL 3036_ GKCGM 3041_ YFVED 3046_ NASDT 3051_ VESSS 3056_ LQGEL 3061_ EPASF 3066_ SWTYE 3071_ EIKEV 3076_ HKRWW 3081_ QLRDN 3086_ AVEIF 3091_ LTNGR 3096_ TLLLA 3101_ FDNTK 3106_ VRDDV 3111_ YHNIL 3116_ TNNLP 3121_ NLLEY 3126_ GNITA 3131_ LTNLW 3136_ YTGQI 3141_ TNFEY 3146_ LTHLN 3151_ KHAGR 3156_ SFNDL 3161_ MQYPV 3166_ FPFIL 3171_ ADYVS 3176_ ETLDL 3181_ NDLLI 3186_ YRNLS 3191_ KPIAV 3196_ QYKEK 3201_ EDRYV 3206_ DTYKY 3211_ LEEEY 3216_ RKGAR 3221_ EDDPM 3226_ PPVQP 3231_ YHYGS 3236_ HYSNS 3241_ GTVLH 3246_ FLVRM 3251_ PPFTK 3256_ MFLAY 3261_ QDQSF 3266_ DIPDR 3271_ TFHST 3276_ NTTWR 3281_ LSSFE 3286_ SMTDV 3291_ KELIP 3296_ EFFYL 3301_ PEFLV 3306_ NREGF 3311_ DFGVR 3316_ QNGER 3321_ VNHVN 3326_ LPPWA 3331_ RNDPR 3336_ LFILI 3341_ HRQAL 3346_ ESDYV 3351_ SQNIC 3356_ QWIDL 3361_ VFGYK 3366_ QKGKA 3371_ SVQAI 3376_ NVFHP 3381_ ATYFG 3386_ MDVSA 3391_ VEDPV 3396_ QRRAL 3401_ ETMIK 3406_ TYGQT 3411_ PRQLF 3416_ HMAHV 3421_ SRPGA 3426_ KLNIE 3431_ GELPA 3436_ AVGLL 3441_ VQFAF 3446_ RETRE 3451_ QVKEI 3456_ TYPSP 3461_ LSWIK 3466_ GLKWG 3471_ EYVGS 3476_ PSAPV 3481_ PVVCF 3486_ SQPHG 3491_ ERFGS 3496_ LQALP 3501_ TRAIC 3506_ GLSRN 3511_ FCLLM 3516_ TYSKE 3521_ QGVRS 3526_ MNSTD 3531_ IQWSA 3536_ ILSWG 3541_ YADNI 3546_ LRLKS 3551_ KQSEP 3556_ PVNFI 3561_ QSSQQ 3566_ YQVTS 3571_ CAWVP 3576_ DSCQL 3581_ FTGSK 3586_ CGVIT 3591_ AYTNR 3596_ FTSST 3601_ PSEIE 3606_ METQI 3611_ HLYGH 3616_ TEEIT 3621_ SLFVC 3626_ KPYSI 3631_ LISVS 3636_ RDGTC 3641_ IIWDL 3646_ NRLCY 3651_ VQSLA 3656_ GHKSP 3661_ VTAVS 3666_ ASETS 3671_ GDIAT 3676_ VCDSA 3681_ GGGSD 3686_ LRLWT 3691_ VNGDL 3696_ VGHVH 3701_ CREII 3706_ CSVAF 3711_ SNQPE 3716_ GVSIN 3721_ VIAGG 3726_ LENGI 3731_ VRLWS 3736_ TWDLK 3741_ PVREI 3746_ TFPKS 3751_ NKPII 3756_ SLTFS 3761_ CDGHH 3766_ LYTAN 3771_ SDGTV 3776_ IAWCR 3781_ KDQQR 3786_ LKQPM 3791_ FYSFL 3796_SSYAA
1: Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed:11984006, PubMed:25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed:25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed:26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733)