Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62)
1_MDGAV 6_ MEGPL 11_ FLQSQ 16_ RFGTK 21_ RWRKT 26_ WAVLY 31_ PASPH 36_ GVARL 41_ EFFDH 46_ KGSSS 51_ GGGRG 56_ SSRRL 61_ DCKVI 66_ RLAEC 71_ VSVAP 76_ VTVET 81_ PPEPG 86_ ATAFR 91_ LDTAQ 96_ RSHLL 101_ AADAP 106_ SSAAW 111_ VQTLC 116_ RNAFP 121_ KGSWT 126_ LAPTD 131_ NPPKL 136_ SALEM 141_ LENSL 146_ YSPTW 151_ EGSQF 156_ WVTVQ 161_ RTEAA 166_ ERCGL 171_ HGSYV 176_ LRVEA 181_ ERLTL 186_ LTVGA 191_ QSQIL 196_ EPLLS 201_ WPYTL 206_ LRRYG 211_ RDKVM 216_ FSFEA 221_ GRRCP 226_ SGPGT 231_ FTFQT 236_ AQGND 241_ IFQAV 246_ ETAIH 251_ RQKAQ 256_ GKAGQ 261_ GHDVL 266_ RADSH 271_ EGEVA 276_ EGKLP 281_ SPPGP 286_ QELLD 291_ SPPAL 296_ YAEPL 301_ DSLRI 306_ APCPS 311_ QDSLY 316_ SDPLD 321_ STSAQ 326_ AGEGV 331_ QRKKP 336_ LYWDL 341_ YEHAQ 346_ QQLLK 351_ AKLTD 356_ PKEDP 361_ IYDEP 366_ EGLAP 371_ VPPQG 376_ LYDLP 381_ REPKD 386_ AWWCQ 391_ ARVKE 396_ EGYEL 401_ PYNPA 406_ TDDYA 411_ VPPPR 416_ STKPL 421_ LAPKP 426_ QGPAF 431_ PEPGT 436_ ATGSG 441_ IKSHN 446_ SALYS 451_ QVQKS 456_ GASGS 461_ WDCGL 466_ SRVGT 471_ DKTGV 476_KSEGS
1: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3